@article{article_599681, title={In patients receiving spinal anesthesia, can homocysteine and C-reactive protein levels predict the development of postdural puncture headache?}, journal={Sabuncuoglu Serefeddin Health Sciences}, volume={1}, pages={34–41}, year={2019}, author={Şahin, Murat and Peker, Kemal and Bozkurt, Ali Seydi}, keywords={Spinal Anesthesia,Postdural Puncture Headache,Homocysteine,C-Reactive Proteine}, abstract={<p class="MsoNormal" style="text-align:justify;line-height:150%;"> <b> <span lang="en-us" xml:lang="en-us">Objectives: </span> </b> <span lang="en-us" xml:lang="en-us">Postdural
puncture headache (PDPH) is a complication that may arise following spinal
anesthesia. We investigated whether homocysteine and C-reactive protein levels may
be associated in the development of PDPH in patients that received spinal
anesthesia. </span> </p> <p> </p> <p class="MsoNormal" style="text-align:justify;line-height:150%;"> <b> <span lang="en-us" xml:lang="en-us">Materials and Methods: </span> </b> <span lang="en-us" xml:lang="en-us">In order to determine homocysteine and C-reactive protein (CRP) levels,
blood samples were taken from patients before and one day following spinal
anesthesia. A total of 100 male patients were enrolled in the study. The mean
age of the patients was 29 years old. Out of all the patients, a total of 6
developed headaches. The Mann-Whitney U-test was used to compare homocysteine
and CRP levels between patients that did and did not develop headaches. </span> </p> <p> </p> <p class="MsoNormal" style="text-align:justify;line-height:150%;"> <b> <span lang="en-us" xml:lang="en-us">Results: </span> </b> <span lang="en-us" xml:lang="en-us">Homocysteine
levels before and after the operation were higher in subjects that developed a
headache as compared to patients that did not develop headaches ( <i>p </i><0.001). CRP
levels did not differ significantly between patients with headaches and
patients that did not experience them ( <i>p </i>>0.05). </span> </p> <p> </p> <p> <b> <span lang="en-us" style="font-size:12pt;font-family:’Times New Roman’, serif;" xml:lang="en-us">Conclusions: </span> </b> <span lang="en-us" style="font-size:12pt;font-family:’Times New Roman’, serif;" xml:lang="en-us"> High blood levels of homocysteine in patients with
PDPH might be used as a biomarker so to predict the development of PDPH.
However, future larger, multi-center studies are needed to further elucidate
this association. </span> <br /> </p>}, number={1}, publisher={Amasya University}, organization={Erzincan Binali Yıldırım Üniversitesi Bilimsel Araştırma Projesi}