TY  - JOUR
T1  - Heterosiklik 4,5-dihidro-1H-1,2,4-triazol-5-on Türevinin Antioksidan Özelliğinin Erkek Ratlarda (Wistar albino) İn vivo Olarak Belirlenmesi
TT  - In vivo Determination of Antioxidant Properties of Heterocyclic 4,5- dihydro-1H-1,2,4-triazole-5-one Derivative in Male Rats (Wistar albino)
AU  - Koç, Evren
AU  - Yüksek, Haydar
AU  - Beytur, Murat
AU  - Akyıldırım, Onur
AU  - Akçay, Mustafa
AU  - Beytur, Cansu
PY  - 2020
DA  - June
Y2  - 2019
DO  - 10.17798/bitlisfen.600412
JF  - Bitlis Eren Üniversitesi Fen Bilimleri Dergisi
PB  - Bitlis Eren University
WT  - DergiPark
SN  - 2147-3129
SP  - 542
EP  - 548
VL  - 9
IS  - 2
LA  - tr
AB  - 4,5-Dihidro-1H-1,2,4-triazol-5-on türevliheterosiklik bileşikler sanayide, tıpta, eczacılıkta ve kimyanın pek çokalanında önemli yere sahiptir. Bu bileşiklerin bazı biyolojik aktiviteözellikleri in vitro olarakincelenmiş olup bazılarının yüksek aktivite gösterdikleri belirlenmiştir. Buaktivitelerden biri de 1,2,4-triazol-5-on türevlerinin göstermiş olduğuantioksidan özelliğidir. Mevcut araştırmada da, 3-metil-4-(3,4-dihidroksibenzilidenamino)-4,5-dihidro-1H-1,2,4-triazol-5-on (3-MTA) bileşiğinin antioksidan özellikgösterip göstermediği ratlarda in vivoolarak spektrofotometrik yöntemle belirlenmiştir. Bu amaçla hayvanlar; kontrolgrubu, DMSO grubu, 10 mg/kg ve 50 mg/kg 3-MTAbileşiği içeren gruplar olacak şekilde 4’e ayrılmıştır. Yapılan spektrofotometrikanalizler neticesinde kontrol grubuna kıyasla serumda 10 ve 50 mg/kg dozunda 3-MTA bileşiği uygulanan gruplarda,böbrek dokusunda ise 50 mg/kg dozunda 3-MTAbileşiği uygulanan grupta total antioksidan düzeyleri artış göstermiştir(P<0.01). Bununla birlikte; böbrek dokusu total oksidan seviyesinin isekontrol grubuna göre 50 mg/kg 3-MTAbileşiği uygulanan grupta azaldığı belirlenmiştir (P<0.01). Sonuç olarak;elde edilen verilere göre, 3-MTAbileşiğinin sıçanlarda uygulanan doz ve sürede toksik etki göstermediği, serumve böbrek TAD düzeyindeki artış ve böbrek TOD düzeyindeki azalmaya göre deolumlu biyolojik aktiviteye sahip olduğu kanısına varılmıştır.
KW  - Triazole
KW  - Schiff base
KW  - TAS
KW  - TOS
N2  - 4,5-Dihydro-1H-1,2,4-triazol-5-one derived heterocyclic compounds have an important place in industry, medicine, pharmacy and many other fields of chemistry. Biological activity properties of these compounds have been examined in vitro, it was determined that some of them show high activity. One of these activities is the antioxidant property of 1,2,4-triazol-5-one derivatives. In the present study, the antioxidant properties of 3-methyl4-(3,4-dihydroxybenzylideneamino)-4,5-dihydro-1H-1,2,4-triazol-5-one (3-MTA) were determined in rats by spectrophotometric method in vivo. For this purpose, animals were divided into 4 groups; control group, dimethyl sulfoxide (DMSO) group, 10 mg/kg and 50 mg/kg including MTA compound groups. As a result of the spectrophotometric analyzes, total antioxidant status (TAS) were increased in the serum treated groups of both 3- MTA compounds (P<0.01) and in the renal tissue treated with only 50 mg / kg 3-MTA compounds (P <0.001). On the other hand, total oxidant status (TOS) of kidney tissue was decreased in 50 mg/kg 3-MTA compound administrated group compared to control group (P <0.05). As a result; according to the obtained data, it was concluded that 3-MTA compound did not show toxic effects in dose and duration of rats and it had positive biological activity according to increase in serum and renal TAS levels and decrease in renal TOS levels.
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UR  - https://doi.org/10.17798/bitlisfen.600412
L1  - https://dergipark.org.tr/en/download/article-file/1144070
ER  -