TY - JOUR T1 - Synthesis and Characterization of Novel 1-(Morpholin-4-yl-methyl)-3-alkyl(aryl)-4-[3-ethoxy-4-(2-furylcarbonyloxy)-benzylidenamino]-4,5-dihydro-1H-1,2,4-triazol-5-ones AU - Akyıldırım, Onur AU - Yuksek, Haydar AU - Manap, Sevda PY - 2019 DA - July JF - The Eurasia Proceedings of Science Technology Engineering and Mathematics JO - EPSTEM PB - ISRES Publishing WT - DergiPark SN - 2602-3199 SP - 96 EP - 100 VL - 6 LA - en AB - Inthis study, six novel 1-(morpholin-4-yl-methyl)-3-alkyl(aryl)-4-[3-ethoxy-4-(2-furylcarbonyloxy)-benzylidenamino]-4,5-dihydro-1H-1,2,4-triazol-5-one (2) compunds weresynthesized from a reaction of type 1 compunds with formaldehyde and morpholine.The finally part contains that synthesis of new compounds. The structures ofthese novel compounds were characterized by using, IR, 1H NMR and 13CNMR spectral data. KW - Schiff bases KW - Mannich bases KW - Synthesis KW - Characterization CR - Alam, M. M., Nazreen, S., Haider, S., Shafi, S., Yar, M. S., Hamid, H., & Alam., M. S. (2012). Synthesis of some new S-Alkylated 1,2,4-triazoles, their Mannich bases and their biological activities. Archiv der Pharmazie-Chemistry in Life Sciences, 345, 203–214. http://doi.org/10.1002/ardp.201100128 Bayrak, H., Demirbas, A., Karaoglu, S. A., Demirbas, N. (2009). Synthesis of some new 1,2,4-triazoles, their Mannich and Schiff bases and evaluation of their antimicrobial activities. European Journal of Medicinal Chemistry, 44, 1057-1066. http://doi.org/10.1016/j.ejmech.2008.06.019 Bekircan, O., Menteşe, E., Ülker, S., & Kucuk., C. (2014). Synthesis of some new 1,2,4-triazole derivatives starting from 3-(4-chlorophenyl)-5-(4-methoxybenzyl)-4H-1,2,4-triazol with anti-lipase and anti-urease activities. Archiv der Pharmazie-Chemistry in Life Sciences, 347, 387–397. http://doi.org/10.1002/ardp.201300344 Bektaş, H., Karaali, N., Şahin, D., Demirbaş, A., Karaoglu, Ş. A., Demirbaş, N. (2010). Synthesis and antimicrobial activities of some new 1,2,4-triazole derivatives. Molecules, 15, 2427-2438. http://doi.org/10.3390/molecules15042427 Demirbas, A., Sahin, D., Demirbas, N., Karaoglu, S. A. (2009). Synthesis of some new 1,3,4-thiadiazol-2-ylmethyl-1,2,4-triazole derivatives and investigation of their antimicrobial activities. European Journal of Medicinal Chemistry, 44, 2896–2903. http://doi.org/10.1016/j.ejmech.2008.12.005 Holla, B. S., Veerendra, B., Shivananda, M. K., Poojary, B. (2003). Synthesis characterization and anticancer activity studies on some Mannich bases derived from 1,2,4-triazoles. European Journal of Medicinal Chemistry, 38, 759–767. http://doi.org/10.1016/S0223-5234(03)00128-4 Nithinchandra, Kalluraya, B., Aamir, S., Shabaraya, A. R. (2012). Regioselective reaction: Synthesis, characterization and pharmacological activity of some new Mannich and Schiff bases containing sydnone. European Journal of Medicinal Chemistry, 54, 597-604. http://doi.org/10.1016/j.ejmech.2012.06.011 Ozdemir, Y., Gultekin, E., & Bekircan, O. (2017). Synthesis and biological significances of new heterocyclic compounds containing 5-(4-chlorobenzyl)-3-(4-chlorophenyl)-1H-1,2,4-triazol ring. Journal of The Chemical Society of Pakistan, 39, 1055–1067. http://doi.org/10.1002/ardp.201300344 Triloknadh, S., Rao, C. V., Nagaraju, K., Krishna, N. H., Ramaiah, C. V., Rajendra, W., Trinath, D., Suneetha, Y. (2018). Design, synthesis, neuroprotective, antibacterial activities and docking studies of novel thieno[2,3-d]pyrimidine-alkyne Mannich base and oxadiazole hybrids. Bioorganic & Medicinal Chemistry Letters, 28, 1663–1669. http://doi.org/10.1016/j.bmcl.2018.03.030 UR - https://dergipark.org.tr/en/pub/epstem/issue//605347 L1 - https://dergipark.org.tr/en/download/article-file/784864 ER -