TY  - JOUR
T1  - Intravenous NAD+ effectively increased the NAD metabolome, reduced oxidative stress and inflammation, and increased expression of longevity genes safely in elderly humans
AU  - Braıdy, Nady
PY  - 2018
DA  - August
DO  - 10.37212/jcnos.610084
JF  - Journal of Cellular Neuroscience and Oxidative Stress
JO  - J Cell Neurosci Oxid Stress
PB  - Yasemin NAZIROĞLU
WT  - DergiPark
SN  - 2149-7222
SP  - 779
EP  - 779
VL  - 10
IS  - 3
LA  - en
AB  - Nicotinamide adenine dinucleotide (NAD+) servesimportant roles in hydrogen transfer and as thecosubstrate for poly(ADP-ribose) polymerase (PARPs),the sirtuin (SIRT1-7) family of enzymes, and CD38glycohydrolases. Recently, intravenous (IV) NAD+therapy has been used as a holistic approach to treatwithdrawal from addiction, overcome anxiety anddepression, and improve overall quality of life withminimal symptoms between 3-7 days of treatment.We evaluated repeat dose IV NAD+ (1000 mg) for6 days in a population of 8 healthy adults between theages of 70 and 80 years.Our data is the first to show that IV NAD+increases the blood NAD+ metabolome in elderlyhumans. We found increased concentrations ofglutathione peroxidase -3 and paraoxonase-1, anddecreased concentrations of 8-iso-prostaglandin F2α,advanced oxidative protein products, protein carbonyl,C-reactive protein and interleukin 6. We reportsignificant increases in mRNA expression and activityof SIRT1, and Forkhead box O1, and reduced acetylatedp53 in peripheral blood mononuclear cells isolated fromthese subjects. No major adverse effects were reportedin this study.The study shows that repeat IV dose of NAD+ is asafe and efficient way to slow down age-related declinein NAD+.
KW  - Nicotinamide adenine dinucleotide
KW  - Oxidative stress
KW  - Inflammation
KW  - Longevity genes
KW  - Elderly humans
CR  - Braidy N, Berg J, Clement J, Khorshidi F, Poljak A, Jayasena T, Grant R, Sachdev P. 2018. NAD+ Precursors as Therapeutic Agents for Age-related Degenerative Diseases. Antioxidant and Redox Signaling. http://doi.org/10.1089/ars.2017.7269
CR  - Braidy N, Grant R, Sachdev P. 2017. Nicotinamide adenine dinucleotide and its related precursors for the treatment of Alzheimer’s disease. Current Opinion in Psychiatry. http://doi.org/10.1097/YCO.0000000000000394.
UR  - https://doi.org/10.37212/jcnos.610084
L1  - https://dergipark.org.tr/en/download/article-file/791736
ER  -