@article{article_611576, title={ACUTE ARTERIAL THROMBOSIS FOLLOWING CAPECITABINE, CISPLATIN, TRASTUZUMAB COMBINATION IN METASTATIC GASTRIC ADENOCARCINOMA}, journal={Duzce Medical Journal}, volume={18}, pages={79–80}, year={2016}, author={Duman, Berna Bozkurt}, keywords={capecitabine, cisplatin, trastuzumab, arterial trombosis}, abstract={The increased risk of thrombosis in patients with active cancer has multiple causes. Althoughvenous thrombosis is more common in patients with cancer than in the general population,chemotherapy-induced arterial thrombosis rarely has been reported. Patients with cancer are ina hypercoagulable state. Cisplatin seems the most responsible from this adverse event. Themechanism by which cisplatin triggers vascular events is unknown, but endothelial damageseems to play a major role. Other proposed hypotheses are cisplatin-induced elevation of plasmalevels of von Willebrand factor, alteration of clotting cascade, thrombaxane–prostacyclinhomeostatic disturbances, and stimulation of fibroblasts. Here we report a rare side effectthat became after capecitabine, cisplatin, trastuzumab combination}, number={2}, publisher={Duzce University}