TY - JOUR T1 - Yeni 2,5-Disubstitüe 1,3,4-Oksadiazol Bileşiklerinin Sentezi TT - Synthesis Of Novel 2,5-Disubstitue 1,3,4-Oxadiazol Compounds AU - Tan, Meltem PY - 2020 DA - April Y2 - 2020 DO - 10.17714/gumusfenbil.612725 JF - Gümüşhane Üniversitesi Fen Bilimleri Dergisi PB - Gumushane University WT - DergiPark SN - 2146-538X SP - 330 EP - 338 VL - 10 IS - 2 LA - tr AB - Yapısında1,3,4- oksadiazol halkası içeren bileşikler geniş bir biyolojik aktivitespektrumuna sahiptir. Genel olarak; antibakteriyel, antifungal, analjezik,antiinflamatuar, antiviral, antikanser, antidiabetik, antihelmintik,antikonvülsan etki gösterdikleri son yıllarda yapılan çalışmalarla ortayakonulmuştur. Bu nedenle bu çalışmada öncelikle prokain bileşiğinden yolaçıkılarak hidrazin hidrat ile reaksiyonları incelendi ve benzohidrazit türevi moleküllerinsentezi yapıldı. Sonrasında bu bileşiklerin asetik anhidrit ve asetik asitvarlığında halka kapanma reaksiyonları ile daha önce literatürde yer almayan ve2,5 konumlarında farklı gruplar içeren 1,3,4-oksadiazol bileşiklerinin sentezigerçekleştirildi. Sentezlenen bileşiklerin antibakteriyel ve antifungalözelliklerinin araştırılması Escherichiacoli ATCC 36218, Staphylococcusaureus ATCC 25923 ve Candida albicansATCC 10231 mikroorganizmaları ile yapıldı. Bileşikler içinde fenilhalkasına bağlı lipofilik asetat grubu bulunduranların antibakteriyel veantifungal özelliklere sahip olduğu gözlendi. KW - Aromatik KW - Biyolojik Aktivite KW - Heterosiklik KW - Oksadiazol N2 - Compounds containing1,3,4-oxadiazole ring in the structure have a broad spectrum of biological activity.Generally; antibacterial, antifungal, analgesic, anti-inflammatory, antiviral,anticancer, antidiabetic, antihelmintic, anticonvulsant effect has beendemonstrated by recent studies. Therefore, in this study, the reaction ofhydrazine hydrate and pirocaine have been investigated and synthesis ofbenzohydrazide derivative molecules has been carried out.Then, by the ring closure of these compounds in thepresence of acetic anhydride and acetic acid, the synthesis of 1,3,4-oxadiazolecompounds which were not previously mentioned in the literature and containingdifferent groups at 2,5 positions was carried out. Investigation ofantibacterial and antifungal properties of synthesized compounds were performedwith Escherichia coli ATCC 36218, Staphylococcus aureus ATCC 25923 and Candidaalbicans ATCC 10231 microorganisms.It was observed that those compounds containing lipophilic acetate group boundto phenyl ring had antibacterial and antifungal properties. CR - Ahsan, M.J., Samy, J.G., Khalilullah, H., Nomani, M.S., Saraswat, P., Gaur, R. ve Singh, A., 2011. 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