TY  - JOUR
T1  - Synthesis of Some New Kind of Antipyrine Carbo(thio)amide and 1,2,4-Triazole Derivatives and Comparing Their Anti-tubercular Activities
TT  - Bazı Yeni Antipirin Karbo (tiyo) amid ve 1,2,4-Triazol Türevlerinin Sentezi ve Anti-tuberküler Aktivitelerinin Karşılaştırılması
AU  - Bayrak, Hacer
AU  - Uygun Cebeci, Yıldız
PY  - 2019
DA  - December
DO  - 10.31466/kfbd.620635
JF  - Karadeniz Fen Bilimleri Dergisi
JO  - KFBD
PB  - Giresun University
WT  - DergiPark
SN  - 2564-7377
SP  - 323
EP  - 334
VL  - 9
IS  - 2
LA  - en
AB  - In this study, antipyrine (4-aminoantipyrine) was selected as the starting material and anti-tubercular activities were compared by carrying out the antipyrine nucleated carbothioamide and 1,2,4-triazole derivatives. The treatment of 4-aminoantipyrine with ethylbromoacetate, hydrazinhydrate and various iso (thio) cyanates, respectively, followed by cyclic reaction by basic reaction resulted in the addition of a second ring of 1,2,4-triazole to the structure. The structures of the synthesized new antipyrine derivatives were determined by spectroscopic methods such as IR, NMR and mass spectrophotometry. For the new compounds synthesized, activity studies were performed against non-Gram bacteria.
KW  - Antipyrine
KW  - 1 2 4-Triazole
KW  - Anti-tubercular Activity
N2  - Buçalışmada antipirin (4-Aminoantipirin) başlangıç maddesi olarak seçilerekkarbotiyoamit ve 1,2,4-triazoltürevi bileşikler gerçekleştirilerek anti-tuberküleraktiviteleri karşılaştırılmıştır. 4-aminoantipirin sırasıyla etilbromoasetat,hidrazinhidrat ve çeşitli izo(tiyo)siyanatlar ile muamelesi sonucu bazikortamda reaksiyonu ile halkalaşma reaksiyonu gerçekleşmesi ile yapıya ikincibir halka olan 1,2,4-triazol halkasının ilavesi gerçekleştirildi. Sentezlenenyeni antipirin türevi bileşiklerin yapıları IR, NMR ve kütle spektrofotometresigibi spektroskopik yöntemlerle aydınlatıldı. Sentezlenen yeni bileşikler, Gramolmayan bakteriye karşı aktivite çalışmaları gerçekleştirilmiştir.
CR  - Abdel-Latif, E., (2006). Phosphorus, Sulfur Silicon Relat. Elem., 181, 125-139.
CR  - Abu-Elmaati, T.M., (2002). Acta Chim. Slov., 49, 721-732.
CR  - Bondock, S., Rabie, R., Etman, H.A. and Fadda, A.A., (2008). Eur. J. Med. Chem., 43, 2122-2129.
CR  - Chandra, J. N. N. S., Sadashiv, C.T., Kavitha, C.V. and Rangappa, K.S., (2006). Bioorg. Med. Chem., 14, 6621-27.
CR  - Demirbaş, N. and Uğurluoğlu, R., (2004). Turk J. Chem., 28, 559-570.
CR  - Demirbaş, N., Uğurluoğlu, R. and Demirbas, A., (2002). Bioorg. Med. Chem., 10, 3717-3723.
CR  - Dixit, P.P., Patil, V.J., Nair, P.S., Jain, S., Sinha, N. and Arora, S.K., (2006). Eur. J. Med. Chem., 41, 423-28.
CR  - Filho, V.C., Correa, Z., Vaz, J.B., Calixto, R.J., Nunes, T.R., Pinheiro, A.D. and Andricopulo, R.A., (1998). Il Framaco, 53, 55-57.
CR  - Gürsoy, A., Demirayak, S., Capan, G., Erol, K. and Vurual, K., (2000). Eur. J. Med. Chem., 35, 359-364.
CR  - Holla, B., S., Sarojini, B., K., Sooryanarayana, R., Akberali, P., M., Kumari, N., S. and Shetty, V., (2001). II Farmaco, 56, 565-570.
CR  - İkizler, A., Demirbaş, N. and İkizler, A., (1996). J Het. Chem., 33, 1765-69.
CR  - İkizler, A.A., Ucar, F.I., Demirbaş, N.D., Yasa, I., Demirbaş, A. and Genzer, T., (1999). Indian j. Pharm. Sci., 61, 271-74.
CR  - İsmail, M.M.F., Ammar, Y.A., El-Zahaby, H.S.A., Eisa, S.I. and Barakat, S.E., (2007). Arch. Pharm. Life Sci., 340, 476-482.
CR  - Jain, S.C., Sinha, J., Bhagat, S., Errington, W. and Olsen, C.E., (2003). Synth. Commun., 33, 563-577.
CR  - Kolavi, G., Hedge, V., Khazi, I, A. and Gadad, P., (2006). Bioorg. Med. Chem., 14, 3069-3080.
CR  - Mishra, A.P., (1999). J. Indian Chem. Soc., 76, 35-37.
CR  - Raman, N., Kulandaisamy, A. and Jeyasubramanian, K., (2002). Synth. React. Inorg. Met., 32, 1583-1610.
CR  - Raman, N., Kulandaisamy, A. and Jeyasubramanian, K., (2004). Synth. React. Inorg. Met., 34, 17-43.
CR  - Rostom, S.A.F., El-Ashmawy, I.M., Abd El Razik, H.A., Badr, M.H. and Ashour, H.M.A., (2009). Bioorg. Med. Chem., 17, 882-895.
CR  - Rostom, S., A., F., Shalaby, M., A. and El-Demellawy, A., (2003). Eur. J. Med. Chem., 38, 959-974.
CR  - Sondhi, S.M., Sharma, V.K., Verma, R.P., Singhal, N., Shukla, R., Raghubir, R. and Dubey, M.P., (1999). Synthesis, 878-884.
CR  - Sondhi, S.M., Singhal, N., Verma, S.K., Arora, S.K. and Dastidar, S.G., (2001). Indian J. Chem., Sect. B, 40, 113-119.
CR  - Sun, S., Lou, H., Gao, Y., Fan, P., Ma, B., Ge, W. and Wang, X., (2004). Journal of Pharmaceutical and Biomedical Analysis, 34, 1117-1124.
CR  - Turan-Zitouni, G., Kaplancikli, Z., A., Erol, K. and Kilic, F., S., (1999). II Farmaco, 54, 218-223.
CR  - Turan-Zitouni, G., Sivaci, M., Kilic, F.S.and Erol, K., (2001). Eur. J. Med. Chem., 36, 685-689.
CR  - Verrect, G., Six, K., Mooter, G. V., Baert, L., Peeters, J. and Brewser, M. E., (2003). International Journal of Pharmaceutics, 251, 165-174.
CR  - Woods, G.L., Brown-Elliott, B.A., Desmond, E.P., Hall, G.S., Heifets, L., Pfyffer, G.E., Ridderhof, J.C., Wallace, R.J., Jr. Warren, N.C. and Witebsky, F.G., (2003). Approved Standard. NCCLS document M24-A, 23, 18.
UR  - https://doi.org/10.31466/kfbd.620635
L1  - https://dergipark.org.tr/en/download/article-file/886614
ER  -