TY - JOUR T1 - Diyabetik Nöropatisi Olan Kişilerde Monosit/HDL Kolesterol Oranı ile Kardiyovasküler Risk Arasındaki İlişki TT - The Relationship Between Monocyte / HDL-Cholesterol Ratio and Cardiovascular Risk in Diabetic Neuropathia AU - Pençe, Halime Hanım AU - Aktaş, Hanife Şerife PY - 2019 DA - December Y2 - 2019 DO - 10.26453/otjhs.620725 JF - Online Turkish Journal of Health Sciences JO - OTSBD PB - Oğuz KARABAY WT - DergiPark SN - 2459-1467 SP - 526 EP - 538 VL - 4 IS - 4 LA - tr AB - Bu çalışmada diyabetin mikrovasküler komplikasyonlarından olan diyabetiknöropatisi olan hastalarda monosit/HDL kolesterol oranı (MHR)’ninkardiyovasküler risk belirteci olup olamayacağının araştırılması amaçlanmıştır.Dahiliye polikliniğimizdeki Ocak 2018- Eylül 2018 tarihleri arasındakihastalardan 30 diyabetik nöropatisi (DN) olan diabetes mellitus (DM) hastası, 29DN olmayan DM hastası ve aynı yaş ve cinsiyette 30 DM olmayan sağlıklıretrospektif olarak çalışmaya alındı. Yaş, cinsiyet, vücut kitle indeksi (BMI),sigara, DM süresi, hipertansiyon, hemogramdaki monosit sayısı, glikozilehemoglobin A1c (HbA1c), total kolesterol, düşük yoğunluklu lipoprotein LDLkolesterol (LDL-K), yüksek yoğunluklu lipoprotein HDL kolesterol (HDL-K),trigliserid (TG) ve mikroalbuminüri, MHR, Framingham Kardiyovasküler RiskSkorlamasına (FCR) göre olan kardiyovasküler risk oranı incelendi. DN ile DN-olmayan diyabetikler arasındaDM süresi açısından fark olduğu görüldü (p<0.05). DN grubun total kolesteroldüzeyleri DN-olmayan gruptan (p<0.05) ve kontrol grubundan (p<0.01) yüksekbulundu. Yine DN grubun HbA1c düzeyleri de daha yüksek bulundu (p<0.001). Kontrolgrubunun FCR skorları DN ve DN olmayan gruptan anlamlı şekilde düşüktü (p<0001).Grupların MHR’si arasında fark bulunmadı. Tüm hastalarda MHR ile HbA1c, FCR skorlarıarasında korelasyon bulundu (Spearman’s rho p <0.05). Bu çalışmada diyabetiknöropatisi olan hastalarda MHR’nin kardiyovasküler risk belirteci olabileceğisonucuna ulaşılamamıştır. Ancak tüm hastalarda MHR ile kardiyovasküler riskarasında bir korelasyon görülmüştür. Bu konuda daha geniş serilerde çalışmayapılmasına ihtiyaç vardır. KW - Diyabetik nöropati KW - kardiyovasküler risk KW - monosit/HDL-K N2 - The aim of this study was to investigatewhether monocyte/HDL cholesterol ratio (MHR) could be a marker ofcardiovascular risk in patients with diabetic neuropathy which is one of themicrovascular complication of diabetes. 30patients with diabetic neuropathy (DN), 30 patients with non-DN- diabetesmellitus (DM), 30 healthy individuals with non-DM same age and sex in ourinternal medicine clinic between January 2018- September 2018 wereretrospectively studied. Age, gender, body mass index (BMI), smoking, hypertension,the number of monocytes, HbA1c, total cholesterol, low density lipoproteinLDL-cholesterol (LDL-C), high density lipoprotein HDL-cholesterol (HDL-C),triglyceride, microalbuminuria, MHR, Framingham Cardiovascular Risk Scoring(FCR) were investigated. There wasa significant difference in the duration of DM between non-DN and diabeticpatients (p <0.05). Total cholesterol levels of DN group were higher thannon-DN group (p <0.05) and control group (p <0.01). The FCR scores of thecontrol group were significantly lower than the DN and non-DN groups (p<0001).There was no difference between MHR and HbA1c and FCR scores in allpatients (Spearman’s rho p <0.05). Inthis study, we could not conclude that MHR can be a predictor of cardiovascularrisk in patients with diabetic neuropathy. However, there was a correlation between cardiovascular risk and MHR inall patients. There is a need for further studies on this subject. CR - 1. Dokken BB. 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