TY  - JOUR
T1  - İLERİ EVRE/REKÜREN OVER KANSERİ NEDENİYLE HİPERTERMİK İNTRAPERİTONYAL KEMOTERAPİ (HIPEC) UYGULADIĞIMIZ HASTALARDAKİ PEROPERATİF TECRÜBEMİZ Our Peroperative Experience in Patients who Underwent Hyperthermic Intraperitoneal Chemotherapy (Hipec) For Advanced Stage/Recurrent Ovarian Cancer
AU  - Kuru, Oğuzhan
AU  - Gökçü, Mehmet
PY  - 2019
DA  - September
DO  - 10.16919/bozoktip.536793
JF  - Bozok Tıp Dergisi
PB  - Yozgat Bozok University
WT  - DergiPark
SN  - 2146-4006
SP  - 65
EP  - 69
VL  - 9
IS  - 3
LA  - tr
AB  - ÖZETAmaç: İleri evre/reküren over kanseri nedeniyle sitoredüktif cerrahi ve Hipertermik İntraperitonyal Kemoterapi(HIPEC) uyguladımız hastalardaki peroperatif morbidite ve mortaliteyi araştırdık.Yöntem: Ocak 2016-Aralık 2018 tarihleri arasında HIPEC uyguladığımız hastaların elektronik dosyaları ve takipleriretrospektif olarak incelendi.Bulgular: Nihai patolojisi musinöz apandiks tümörü gelen 1 vaka dışlandığında peritonyal karsinomatozis nedeniyletoplam 18 hastaya ileri cerrahi ve HIPEC uygulandı. Hastaların ortalama yaşı 54,6 (aralık, 22-76 yaş)idi. Median preoperatif CA125 değeri 64 U/ml (aralık, 6-4756 U/ml) idi. 3 hasta rekürens nedeniyle, 15 hasta(11 interval, 4 first-look cerrahi) ise primer olarak opere edildi. Hastaların hepsine peritonektomi prosedürü,4 hastaya ise beraberinde barsak rezeksiyonu uygulandı. Ortalama operasyon süresi 323,5 dakika (aralık, 180-495 dakika) idi. En sık gözlenen dahili morbidite, kan transfüzyonu (83.3%, 15/18); cerrahi morbidite ise yarayeri enfeksiyonu (%16.6, 3/18) bulundu. Hastaların ortalama hastanede yatış süresi 10,3 gün (aralık, 5-32 gün)idi. Peroperatif mortalite gözlenmedi.Sonuç: HIPEC, yoğun bakım koşulları iyi olan ve multidisipliner kliniklerde uygulandiğında peroperatif ciddimorbidite ve mortaliteye neden olmayan bir yöntemdir.Anahtar Sözcükler: HIPEC; Peroperatif; Morbidite.ABSTRACTObjective: We investigated peroperative morbidity and mortality in patients who underwent cytoreductivesurgery and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for advanced stage/recurrent ovariancancer.Methods: Between January 2016 and December 2018, electronic files and follow-up of patients whounderwent HIPEC were reviewed retrospectively.Results: After one case of mucinous appendiceal tumor was excluded, a total of 18 patients underwentadvanced surgery and HIPEC due to peritoneal carcinomatosis were detected. The mean age of the patientswas 54.6 years (range, 22-76 years). The median preoperative CA125 value was 64 U/ml (range 6-4756 U/ml). Fifteen patients (11 interval surgeries, 4 first-look surgeries) were operated primarily while 3 patientswere operated due to recurrent disease. Peritonectomy procedure was performed in all patients and bowelresection was performed in 4 patients. The mean operative time was 323.5 minutes (range, 180-495 minutes).The most common medical morbidity was blood transfusion (83.3%, 15/18) while most common surgicalmorbidity was wound infection (16.6%, 3/18). The mean length of hospitalization was 10.3 days (range, 5-32days). No peroperative mortality was observed.Conclusion: HIPEC is a method that does not cause severe morbidity and mortality when well intensive careconditions are applied in multidisciplinary clinics.Keywords: HIPEC; Peroperative; Morbidity.
KW  - İLERİ EVRE/REKÜREN OVER KANSERİ NEDENİYLE HİPERTERMİK İNTRAPERİTONYAL KEMOTERAPİ (HIPEC) UYGULADIĞIMIZ HASTALARDAKİ PEROPERATİF TECRÜBEMİZ Our Peroperative Experience in Patients who Underwent Hyperthermic Intraperitoneal Chemotherapy (Hipec) For Advanced Stage/Recurrent Ovarian Cancer
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UR  - https://doi.org/10.16919/bozoktip.536793
L1  - https://dergipark.org.tr/en/download/article-file/811125
ER  -