@article{article_622038, title={Novel Methyl 4,6-O-Benzylidene--D-Glucopyranoside Derivatives: Synthesis, Structural Characterization and Evaluation of Antibacterial Activities}, journal={Hacettepe Journal of Biology and Chemistry}, volume={47}, pages={153–164}, year={2019}, DOI={10.15671/hjbc.622038}, author={Islam, Mirajul and Arifuzzaman, Arifuzzaman and Rahman, Monjur and Rahman, Mohammad Atiar and Kawsar, Sarkar Mohammad Abe Kawsar}, keywords={Synthesis, benzylidene, acylation, structure, pathogens}, abstract={<div style="text-align:justify;">Carbohydrates are the most abundant and the most diverse biopolymers in nature. Due to the importance of carbohydrates  <span style="font-size:.9em;">it is necessary to develop a new method for the synthesis of carbohydrate based drugs of the current global  </span> <span style="font-size:.9em;">situation for health and disease. In this present work we demonstrate the synthesis of methyl 4,6-O-benzylidene--Dglucopyranoside  </span> <span style="font-size:.9em;">derivatives by direct acylation method. The structures of the newly prepared compounds have been characterized  </span> <span style="font-size:.9em;">and elucidated using various physico-chemical and spectroscopic methods including elemental analysis, melting  </span> <span style="font-size:.9em;">point determination, infrared and proton NMR spectroscopy. A number of acyl derivatives were prepared in order to obtain  </span> <span style="font-size:.9em;">a series of newer components for antibacterial screening experiments. These acylated derivatives were evaluated for in  </span> <span style="font-size:.9em;">vitro antibacterial screening studies against four human pathogenic bacteria by disc diffusion method. </span> </div>}, number={2}, publisher={Hacettepe University}