TY  - JOUR
T1  - ACİL SERVİSE BAŞVURAN HASTALARDA AKUT KORONER SENDROMUN DİURNAL VARYASYONUN KORONER ANJİYOGRAFİYE GÖRE DEĞERLENDİRİLMESİ Evaluation of Acute Coronary Syndrome with Coronary Angiography Due To Diurnal Variation in the Patients who Admitted to The Emergency Department
AU  - Çaltekin, İbrahim
AU  - Hidayet, Şiho
AU  - Albayrak, Levent
AU  - Gökçen, Emre
AU  - Savrun, Atakan
AU  - Kuşdoğan, Mikail
AU  - Turan, Yaşar
PY  - 2019
DA  - September
DO  - 10.16919/bozoktip.591272
JF  - Bozok Tıp Dergisi
PB  - Yozgat Bozok University
WT  - DergiPark
SN  - 2146-4006
SP  - 146
EP  - 150
VL  - 9
IS  - 3
LA  - tr
AB  - ÖZETAmaç: Bu çalışmanın amacı, akut miyokard enfarktüslü hastaların diurnal varyasyon gösterip göstermediğinive etkilenen koroner arter ile bu diurnal varyasyon arasındaki ilişkiyi araştırmaktır.Material ve Metodlar: Ocak-Aralık 2017 tarihleri arasında akut koroner sendrom semptomları ile YozgatBozok Üniversitesi Acil Servisine başvuran hastalar retrospektif olarak incelendi. 24 saatlik zaman dilimi içindediurnal değişimler 6 grupta (00:01-04:00, 04:01-08:00, 08:01-12:00, 12:01-16:00, 16:01-20:00, 20:01-00:00), mevsimsel değişimler 4 grupta (İlkbahar, Yaz, Sonbahar, Kış), haftalık değişimler ise 2 grupta (Haftaiçi, Hafta sonu) analiz edilmiştir.Bulgular: Koroner arterlerin gün içindeki diurnal etkilenimleri incelendiğinde istatistiksel olarak anlamlı birsonuç bulunamadı. Diurnal etkilenimin hafta içi ile hafta sonu değişimleri incelendiğinde ise hafta içi olgularındaher üç koroner arter lezyonlarının hafta sonu görülen lezyonlara oranla istatistiksel olarak artmışolduğu saptandı (p<0,05).Sonuç: Çalışmamızın sonucu olarak günlük değişkenlik tespit edilmediyse de, koroner arter hastalığının artmasının,hafta içi günlerde stres ve yoğun iş temposu gibi sosyal nedenlerden etkilendiği açıkça belirlenmiştir.Anahtar kelimeler: Diurnal ritim; Myocard infartüsü; Acil servisABSTRACTBackround: The aim of this study is to investigate whether patients with acute myocardial infarction exhibiteddiurnal variation and the relationship between the affected coronary artery and this diurnal variation.Material and Methods: The patients admitted to the emergency department of Yozgat Bozok Universitywith symptoms of acute coranary syndrome between January and December 2017 were retrospectivelyanalyzed. In 24 hour period diurnal changes were analyzed in 6 groups (00:01-04:00, 04:01-08:00, 08:01-12:00, 12:01-16:00, 16:01-20:00, 20:01-00:00), seasonal changes were analyzed in 4 groups (Spring,Summer, Autumn, Winter), and weekly changes were analyzed in 2 groups (Weekday, Weekend).Results: When diurnal effects coronary arteries were examined, no statistically significant results werefound. When the changes of diurnal effect were observed at weekdays and weekends, it was found thatall three coronary artery lesions were statistically increased at weekdays compared to the lesions seen atweekends (p<0,05).Conclusion: Although daily diurnal variability was not detected as a result of our study, it was clearlydetermined that the increase in coronary artery disease was affected by social reasons such as stress andintensive work pace during the weekdays.Keywords: Diurnal rhytm; Myocardial infarction; Emergency department
KW  - ACİL SERVİSE BAŞVURAN HASTALARDA AKUT KORONER SENDROMUN DİURNAL VARYASYONUN KORONER ANJİYOGRAFİYE GÖRE DEĞERLENDİRİLMESİ Evaluation of Acute Coronary Syndrome with Coronary Angiography Due To Diurnal Variation in the Patients who Admitted to The Emergency Department
CR  - 1. Dominguez-Rodriguez A, Abreu-Gonzalez P, Kaski JC. Inflammatory systemic biomarkers in setting acute coronary syndromes--effects of the diurnal variation. Current drug targets. 2009;10(10):1001-8.
2. Bae MH, Ryu HM, Lee JH, Lee JH, Kwon YS, Lee SH, et al. The impact of circadian variation on 12-month mortality in patients with acute myocardial infarction. Korean circulation journal. 2010;40(12):616-24.
3. Suarez-Barrientos A, Lopez-Romero P, Vivas D, Castro-Ferreira F, Nunez-Gil I, Franco E, et al. Circadian variations of infarct size in acute myocardial infarction. Heart (British Cardiac Society). 2011;97(12):970-6.
4. Sayer JW, Wilkinson P, Ranjadayalan K, Ray S, Marchant B, Timmis AD. Attenuation or absence of circadian and seasonal rhythms of acute myocardial infarction. Heart (British Cardiac Society). 1997;77(4):325-9.
5. Reiter R, Swingen C, Moore L, Henry TD, Traverse JH. Circadian dependence of infarct size and left ventricular function after ST elevation myocardial infarction. Circulation research. 2012;110(1):105-10.
6. Durgan DJ, Young ME. The cardiomyocyte circadian clock: emerging roles in health and disease. Circulation research. 2010;106(4):647-58.
7. Leiza JR, de Llano JM, Messa JB, Lopez CA, Fernandez JA. New insights into the circadian rhythm of acute myocardial infarction in subgroups. Chronobiology international. 2007;24(1):129-41.
8. Jones-Crawford JL, Parish DC, Smith BE, Dane FC. Resuscitation in the hospital: circadian variation of cardiopulmonary arrest. The American journal of medicine. 2007;120(2):158-64.
9. Gami AS, Howard DE, Olson EJ, Somers VK. Day-night pattern of sudden death in obstructive sleep apnea. The New England journal of medicine. 2005;352(12):1206-14.
10. Seneviratna A, Lim GH, Devi A, Carvalho LP, Chua T, Koh TH, et al. Circadian Dependence of Infarct Size and Acute Heart Failure in ST Elevation Myocardial Infarction. PloS one. 2015;10(6):e0128526.
UR  - https://doi.org/10.16919/bozoktip.591272
L1  - https://dergipark.org.tr/en/download/article-file/812575
ER  -