TY - JOUR T1 - KONFLUENT VE RETİKÜLER PAPİLLOMAZTOZİSLİ İKİ OLGU SUNUMU Two Case Reports With Confluent and Reticulated Papillomatosis AU - Gürel, Gülhan AU - Şahin, Sevinç AU - Çölgeçen, Emine PY - 2019 DA - September DO - 10.16919/bozoktip.511933 JF - Bozok Tıp Dergisi PB - Yozgat Bozok University WT - DergiPark SN - 2146-4006 SP - 157 EP - 160 VL - 9 IS - 3 LA - tr AB - ÖZETKonfluent ve retiküler papillomatozis, 1927 yılında Gougerot ve Carteaud tarafından ilk kez tanımlanmıştır. Nadirgörülen bu hastalık daha çok adolesanları etkileyen, birleşmeye eğilimli retiküler paternde hiperkeratotiklezyonlarla karakterizedir. Patofizyolojisi halen net olarak bilinmemektedir, tedaviye dirençlidir ve rekürrenslersık görülmektedir. Pitriyazis versikolor, akantozis nigrikans, prurigo pigmentosa, Darier hastalığı, epidermalnevüs, kutanöz amiloidoz, Dowling-Degos hastalığı, iktiyozis, seboreik dermatit ve parapsoriazis gibi hastalıklarda ayırıcı tanıda akla gelmelidir. KRP’nin tedavisi oldukça zordur. Tedavi seçenekleri arasında topikal ve sistemikretinoidler, topikal kalsipotriol, topikal 5 fluorourasil, topikal antifungaller, mupirosin, topikal takrolimus, oralamoksisilin, eritromisin, azitromisin, minosiklin, fototerapi ve dermabrazyon yer almaktadır. Burada 14 yaşındave 25 yaşında konfluent ve retiküler papillomatozis tanısı konulan iki kadın olgu sunulmaktadır.Anahtar kelimeler: İsotretinoin; Konfluent ve retiküler papillomatozis; Pitriyazis versikolorABSTRACTConfluent and reticulated papillomatosis was first described in 1927 by Gougerot and Carteaud. It is a raredisease that predominantly affects adolescents and is characterized by hyperkeratotic lesions that coalesceinto a reticulated pattern. Pathophysiology is still unclear, treatment is resistant and recurrences are common.Diseases such as pityriasis versicolor, acanthosis nigricans, prurigo pigmentosa, Darier's disease, epidermalnevus, cutaneous amyloidosis, Dowling-Degos disease, ichthyosis, seborrheic dermatitis and parapsoriasisshould be considered in the differential diagnosis. Treatment of confluent and reticulated papillomatosis isvery difficult. Treatment options of confluent and reticulated papillomatosis included topical and systemicretinoids, topical calcipotriol, topical 5 fluorouracil, topical antifungals, mupirocin, topical tacrolimus, oralamoxicillin, erythromycin, azithromycin, minocycline, phototherapy and dermabrasion . Here we present twocases of 14-year-old and 25-year-old female diagnosed as confluent and reticular papillomatosis.Keywords: Isotretinoin; Confluent and reticular papillomatosis; Pityriasis versicolor KW - KONFLUENT VE RETİKÜLER PAPİLLOMAZTOZİSLİ İKİ OLGU SUNUMU Two Case Reports With Confluent and Reticulated Papillomatosis CR - 1. Scheinfeld N. Confluent and reticulated papillomatosis : a review of the literature. Am J Clin Dermatol. 2006;7(5):305-13. 2. Tirado-Sánchez A, Ponce-Olivera RM. Tacrolimus in confluent and reticulated papillomatosis of Gougerot Carteaud. Int J Dermatol. 2013;52(4):513-4. 3. Ferreira LM, Diniz LM, Ferreira CJ. [Confluent and reticulated papillomatosis of Gougerot and Carteaud: report of three cases]. An Bras Dermatol. 2009;84(1):78-81. 4. Treat JR, Barak OG, James WD. Nonpigmenting confluent and reticulated papillomatosis. Pediatr Dermatol. 2006;23(5):497-9. 5. Lee SW, Loo CH, Tan WC. Confluent and reticulated papillomatosis: Case series of 3 patients from Kedah, Malaysia and literature review. Med J Malaysia. 2018;73(5):338-9. 6. Lim JH, Tey HL, Chong WS. Confluent and reticulated papillomatosis: diagnostic and treatment challenges. Clin Cosmet Investig Dermatol. 2016;9:217-23. 7. Jimbow M, Talpash O, Jimbow K. Confluent and reticulated papillomatosis: clinical, light and electron microscopic studies. Int J Dermatol. 1992;31(7):480-3. 8. Natarajan S, Milne D, Jones AL, Goodfellow M, Perry J, Koerner RJ. Dietzia strain X: a newly described Actinomycete isolated from confluent and reticulated papillomatosis. Br J Dermatol. 2005;153:825-7. 9. Jones AL, Koerner RJ, Natarajan S, Perry JD, Goodfellow M. Dietzia papillomatosis sp. nov., a novel actinomycete isolated from the skin of an immunocompetent patient with confluent and reticulated papillomatosis. Int J Syst Evol Microbiol. 2008;58(Pt 1):68-72. 10. Bernardes Filho F, Quaresma MV, Rezende FC, Kac BK, Nery JA, AzulayAbulafia L. Confluent and reticulate papillomatosis of Gougerot-Carteaud and obesity: dermoscopic findings. An Bras Dermatol. 2014; 89(3): 507–9 UR - https://doi.org/10.16919/bozoktip.511933 L1 - https://dergipark.org.tr/en/download/article-file/812596 ER -