@article{article_623353, title={The Effect of Radiotherapy Technique on Carotid Artery Dose in Patients with Early Stage Glottic Larynx Cancer}, journal={Medical Journal of Süleyman Demirel University}, volume={28}, pages={9–12}, year={2021}, DOI={10.17343/sdutfd.623353}, author={Şirin Özdemir, Beyza and Can, Zeynep Rukiye Özge}, keywords={Radiotherapy,glottic cancer,carotid artery,3DCRT,IMRT}, abstract={<h1 style="line-height:200%;"> <b style="text-align:justify;font-size:.9em;"> <span lang="en-us" style="font-size:12pt;line-height:200%;font-family:’Times New Roman’, serif;" xml:lang="en-us">Objective: </span> </b> <span lang="en-us" style="text-align:justify;font-size:12pt;line-height:200%;font-family:’Times New Roman’, serif;" xml:lang="en-us">The
aim of this study was to compare two radiotherapy techniques in early stage
glottic laryngeal cancer patients in terms of radiotherapy dose applied to the
carotid artery. </span> <br /> </h1> <p class="MsoHeader" style="margin-bottom:12pt;text-align:justify;line-height:200%;"> <b> <span lang="en-us" style="font-size:12pt;line-height:200%;font-family:’Times New Roman’, serif;" xml:lang="en-us">Material - Methods: </span> </b> <span lang="en-us" style="font-size:12pt;line-height:200%;font-family:’Times New Roman’, serif;" xml:lang="en-us">In this study, we <span>included </span>10 early-stage (T1/2) glottic larynx cancer
patients. <span>Both intensity-modulated
radiotherapy (IMRT) and 3-dimension conformal radiotherapy (3DCRT) treatment
plans were prepared for each patient. Treatment volumes (CTV, PTV) were created
for all patients. The entire larynx was described as CTV to include both false
and true vocal cords, anterior-posterior commissures, arytenoids, aryepiglottic
folds, subglottic region. For planning target volüme (PTV), while 5-mm was added
to CTV in all directions, 3-mm margin was given to protect the carotid artery
and spinal cord in posterolaterally. Spinal cord and carotid artery were
contoured as the organ at risk (OAR). The doses of the target volumes, the OAR
volumes, the homogeneity index (HI) were compared. </span> </span> </p> <p> </p> <p class="MsoHeader" style="margin-bottom:12pt;text-align:justify;line-height:200%;"> <b> <span lang="en-us" style="font-size:12pt;line-height:200%;font-family:’Times New Roman’, serif;" xml:lang="en-us">Results: </span> </b> <span lang="en-us" style="font-size:12pt;line-height:200%;font-family:’Times New Roman’, serif;" xml:lang="en-us">PTV
parameters (Dmin, Dmean, Dmax, D90, D95) was compared in the 2 different
technique.  IMRT in comparison to 3DCRT
significantly reduced the high-dose volumes (V30, V35, V50) of carotid artery
(p < 0.001), but not to the low dose volume (V10). CI was similar (0.9 vs.
0.9, p = 0.3) compared to 3DCRT. However, HI was significantly improved with
IMRT (0.1 vs. 0.08, p < 0.001). The maximum dose of the spinal cord was lower in
3DCRT compared to IMRT (18 Gy vs. 44Gy). </span> </p> <p> </p> <p> </p> <p class="MsoHeader" style="margin-bottom:12pt;text-align:justify;line-height:200%;"> <b> <span lang="en-us" style="font-size:12pt;line-height:200%;font-family:’Times New Roman’, serif;" xml:lang="en-us">Conclusion: </span> </b> <span lang="en-us" style="font-size:12pt;line-height:200%;font-family:’Times New Roman’, serif;" xml:lang="en-us">IMRT
is a superior radiotherapy (RT) technique in patients with T1/T2 glottic cancer
in terms of protecting carotid artery. </span> </p> <p> </p>}, number={1}, publisher={Süleyman Demirel University}