TY  - JOUR
T1  - Opere Dev Tiroid Nodüllerinde Malignite Oranı ve Sitolojinin Güvenilirliği
TT  - Malignancy Rate and Reliability of Cytology in Operated Giant Thyroid Nodules
AU  - Evranos Öğmen, Berna
AU  - Genç, Birgül
AU  - Polat, Şefika Burçak
PY  - 2019
DA  - September
DO  - 10.17098/amj.624545
JF  - Ankara Medical Journal
JO  - Ankara Med J
PB  - Ankara Yildirim Beyazit University
WT  - DergiPark
SN  - 2148-4570
SP  - 622
EP  - 627
VL  - 19
IS  - 3
LA  - tr
AB  - Amaç: Tiroid nodüllerinde operasyonkararının en önemli belirleyicisi ultrason özellikleri ile birlikte altınstandart olarak kabul edilen sitolojidir. Dev nodüller sitoloji benignse takipmi edilmeli yoksa sitoloji sonucundan bağımsız olarak opere mi edilmeli henüznetleştirilmemiştir. Bu çalışmanın amacı opere olmuş dev nodüllerde maligniteve İİAB'ın yanlış negatiflik oranlarını belirlemektir.Materyal ve Metot: Bu çalışmayaHaziran 2015- Nisan 2019 tarihleri arasında ≥ 4 cm çaplı nodülü olan 675 hastadahil edilmiştir. Bu hastaların 226 'sı opere edilmiş ve verileri retrospektifolarak incelenmiştir. Bulgular: Histopatolojik incelemedebu nodüllerin 37'si (14.40%) malign, 220’si (85.60%) benigndi. Benign ve malignnodüllerin ultrasonografik özellikleri ve nodül çapları arasında anlamlıfarklılık saptanmadı. İki grup demografik özellikler açısından benzerbulunurken, TSH düzeyi malign nodüllerde daha yüksekti. Sitolojinin yanlışnegatiflik oranı dev nodüller için %11.65’di.Sonuç: Sonuç olarak dev nodüllerdecerrahi kararı verirken sitoloji ve ultrason özellikleri ve bası semptomuvarlığı veya kozmetik problem varlığı göz önünde bulundurulmalıdır. Sitolojideyanlış negatiflik oranı küçük nodüllerden yüksek olabilir bu nedenle takipteultrason ve gerektiğinde tekrarlayan biyopsi yapmak gerekir. Bu bulgular rutincerrahi önermek için yeterli değildir.
KW  - Dev nodül
KW  - sitoloji
KW  - malignite oranı
N2  - Objectives: The main determinants of surgerydecision for thyroid nodules are cytology and ultrasonography. It is stilldebated in the literature if the giant nodules should be routinely operateddespite benign cytology reports. This study aimed to determine the malignancyrate in operated giant nodules and calculate the false negativity of cytologyin that group.Materials and Methods We enrolled 675 patients with giantnodules who were followed in our clinics between the dates of June 2015 andApril 2019. We evaluated the malignancy rates and other hormonal anddemographic parameters of 226 patients who underwent an operation and hadhistopathology result, retrospectivelyResults: According to thehistopathology results; 37 (14.40%) of the giant nodules were malignant whereas220 (85.60%) were benign. There was no statistically significant differencebetween malign and benign groups regarding preoperative ultrasonographicfeatures, nodule size and demographic properties. TSH was higher in themalignant group. False negativity of the cytology was calculated as 11.65%.Conclusion: Decision of surgeryshould be based on ultrasonography findings and FNAC in giant thyroid nodules.Routine surgery is not recommended. Repeated biopsies and sampling thedifferent parts of the nodule during a biopsy can decrease the false negativeresults.
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UR  - https://doi.org/10.17098/amj.624545
L1  - https://dergipark.org.tr/en/download/article-file/818499
ER  -