TY  - JOUR
T1  - Changes in antral follicle count and ovarian volume with age
AU  - Kaya, Aysegul
AU  - Kurtoglu, Emel
AU  - Kokcu, Arif
AU  - Alper, Tayfun
AU  - Çetinkaya, Mehmet Bilge
PY  - 2019
DA  - October
Y2  - 2016
JF  - Deneysel ve Klinik Tıp Dergisi
JO  - J. Exp. Clin. Med.
PB  - Ondokuz Mayıs University
WT  - DergiPark
SN  - 1309-4483
SP  - 57
EP  - 61
VL  - 35
IS  - 3
LA  - en
AB  - We aimed to ascertain the chronologicage at which these sonographic measurements begin to show a significantdifference. The study included 100 women (78, aged 19-44 and 22, aged 45-50)menstruated spontaneously and without thyroid disease, diabetes mellitus,hyperprolactinaemia, hypogonadotropic hypogonadism or polycystic ovary syndromeand any gynaecologic surgery. They all underwent sonographic measurement oftotal antral follicle (TAF) count and mean ovarian volume (MOV) on the secondor third days of menstrual cycle. Then, the women were assigned to 5 groups: group1, 19–24 years; group 2, 25–29 years; group 3, 30–37 years; group 4, 38-44years; and group 5, 45-50 years. Therewas a significant association between chronological age and TAF number (r² =0.328, p < 0.001). No significant difference was noted in TAF number amongthe first three groups (² = 0.58, p > 0.05). TAF number was significantly different between groups 3 and 4(Z: -3.463, p < 0.001), but not between groups 4 and 5 (Z: -1.698, p >0.05). There was a significantrelationship between chronological age and MOV (r² = 0.149, p < 0.001). MOVvalues did not show a significant difference among the first 4 groups(² = 0.58, p> 0.05; ² = 7.87, p > 0.05 respectively). The MOV of group 5 was significantly different from those ofgroups 1, 2, 3, and 4 (Z: -2.75, p < 0.01; Z: -4.351, p < 0.01; Z:-2.722, p < 0.01; and Z: -2.829, p < 0.01 respectively). In conclusion, theTAF count decreases significantly beginning at 38 years of age, while MOVdecreases significantly beginning at 45 years of age. Thus, there is nosignificant decrease in the ovarian follicular reserve until the age of 38years, or in the ovarian volume until the age of 45 years. 
KW  - Age
KW  - Ovarian reserve
KW  - Ovarian volume
KW  - Total antral follicle
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UR  - https://dergipark.org.tr/en/pub/omujecm/issue//634938
L1  - https://dergipark.org.tr/en/download/article-file/843920
ER  -