@article{article_635479, title={In vitro anti-leishmanial activity of Sarcopoterium spinosum against Leishmania tropica}, journal={Ankara Üniversitesi Veteriner Fakültesi Dergisi}, volume={65}, pages={373–377}, year={2018}, DOI={10.1501/Vetfak_0000002870}, author={Can, Hüseyin and Kayalar, Hüsniye and Bozkurt, Buket and Can, Şengül and Döşkaya, Mert and Töz, Seray}, keywords={Anti-leishmanial activity, in vitro, Leishmania tropica, Sarcopoterium spinosum}, abstract={<span class="fontstyle0">Complex clinical symptoms such as ulcerative skin lesions, destructive mucosal inflammation, and disseminated <br />visceral infection can reveal in leishmaniasis. The conventional drugs are toxic and expensive. In addition, patients receive a long <br />treatment with these drugs which have adverse effects and unfortunately there are some limitations during the treatment. The aim of <br />this study is to investigate the </span> <span class="fontstyle2">in vitro </span> <span class="fontstyle0">anti-leishmanial activities of four different extracts of </span> <span class="fontstyle2">Sarcopoterium spinosum </span> <span class="fontstyle0">against <br /> </span> <span class="fontstyle2">Leishmania tropica </span> <span class="fontstyle0">. Initially, different concentrations of ethanol, methanol, n-hexane, and water extracts of </span> <span class="fontstyle2">S. spinosum </span> <span class="fontstyle0">were incubated <br />with </span> <span class="fontstyle2">L. tropica </span> <span class="fontstyle0">promastigotes. After 72 hours of incubation, the growth of </span> <span class="fontstyle2">L. tropica </span> <span class="fontstyle0">promastigotes was significantly inhibited and the <br />percentage of inhibition ranged between 42.8 and 100 %. Among these extracts, the most efficient growth inhibition (100 %) was <br />obtained with methanol extract (at a dose of 50 µg/ml). In conclusion, </span> <span class="fontstyle2">S. spinosum </span> <span class="fontstyle0">may be a potential source for the development of <br />novel therapeutic agents to treat </span> <span class="fontstyle2">L. tropica </span> <span class="fontstyle0">infection. </span>   <br style="line-height:normal;" />}, number={4}, publisher={Ankara University}