TY  - JOUR
T1  - In vitro anti-leishmanial activity of Sarcopoterium spinosum against Leishmania tropica
AU  - Can, Hüseyin
AU  - Kayalar, Hüsniye
AU  - Bozkurt, Buket
AU  - Can, Şengül
AU  - Döşkaya, Mert
AU  - Töz, Seray
PY  - 2018
DA  - November
DO  - 10.1501/Vetfak_0000002870
JF  - Ankara Üniversitesi Veteriner Fakültesi Dergisi
JO  - Ankara Univ Vet Fak Derg
PB  - Ankara University
WT  - DergiPark
SN  - 1300-0861
SP  - 373
EP  - 377
VL  - 65
IS  - 4
LA  - en
AB  - Complex clinical symptoms such as ulcerative skin lesions, destructive mucosal inflammation, and disseminatedvisceral infection can reveal in leishmaniasis. The conventional drugs are toxic and expensive. In addition, patients receive a longtreatment with these drugs which have adverse effects and unfortunately there are some limitations during the treatment. The aim ofthis study is to investigate the in vitro anti-leishmanial activities of four different extracts of Sarcopoterium spinosum againstLeishmania tropica. Initially, different concentrations of ethanol, methanol, n-hexane, and water extracts of S. spinosum were incubatedwith L. tropica promastigotes. After 72 hours of incubation, the growth of L. tropica promastigotes was significantly inhibited and thepercentage of inhibition ranged between 42.8 and 100 %. Among these extracts, the most efficient growth inhibition (100 %) wasobtained with methanol extract (at a dose of 50 µg/ml). In conclusion, S. spinosum may be a potential source for the development ofnovel therapeutic agents to treat L. tropica infection.
KW  - Anti-leishmanial activity
KW  - in vitro
KW  - Leishmania tropica
KW  - Sarcopoterium spinosum
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UR  - https://doi.org/10.1501/Vetfak_0000002870
L1  - https://dergipark.org.tr/en/download/article-file/835332
ER  -