@article{article_635491, title={A genomic investigation on hybrid sterility in house mouse using a two stage model}, journal={Ankara Üniversitesi Veteriner Fakültesi Dergisi}, volume={65}, pages={387–393}, year={2018}, DOI={10.1501/Vetfak_0000002872}, author={Karacaören, Burak}, keywords={Bayesian mixture model, genome wide association analyses, pleiotropy}, abstract={<span class="fontstyle0">Genome wide association studies (GWASs) commonly used to search for genetic variants associated with <br />quantitative traits. Pleiotropic effect of genes may cause the observed correlations among different phenotypes. This study proposed a <br />two stage multilocus model for pleiotropic GWAS using a Bayesian mixture model to take into account of both small and major gene <br />effects. The objectives of this study were to investigate if the two-stage model was useful for detecting pleiotropic genes using a <br />simulated data set and to investigate existence of pleiotropic genes for testis weight and testis gene expression levels in house mouse. <br />The analyses included relative testis weight and testis gene expression traits. The results showed that two stage model had higher power <br />to detect the pleiotropic QTL than the single marker model. It was also noted the possible economical impact of sampling informative <br />individuals for the GWAS analyses by observing genomic trends in the simulated dataset. Two stage model detected 50 and 53 major <br />SNP effects using first and the second principal components. Additive genetic variation explained by chromosome X was found to be <br />4% for the testis weight. </span>   <br style="line-height:normal;" />}, number={4}, publisher={Ankara University}