@article{article_637127, title={Novel oxidative stress biomarker in sepsis: dynamic thiol-disulfide homeostasis}, journal={Cukurova Medical Journal}, volume={45}, pages={63–70}, year={2020}, DOI={10.17826/cumj.637127}, author={Kozanhan, Betül and Eğilmez, Ayşe İlksen and Tok Cekmecelioglu, Busra and Tutar, Mahmut Sami and Eren, Gulay and Bilgi Özel, Deniz and Damla Deniz, Çiğdem and Neşelioğlu, Salim and Erel, Ozcan}, keywords={Dynamic thiol-disulfide homeostasis,Sepsis}, abstract={<p>Purpose: The aim of this study was to investigate the relationship between serum dynamic thiol-disulfide homeostasis (TDH) and sepsis, in adult patients. <br />Materials and Methods: In this observational, prospective, case-control study patients (n=44) diagnosed with sepsis compared with ages and gender-matched healthy controls (n=44). Patients were divided into two subgroups (survivors and non-survivors) dependent variable being remaining alive on the 28th day after ICU admission at the follow-up period. TDH parameters measured using a novel automatic and spectrophotometric method and compared statistically. <br />Results: In patients with sepsis, native thiol, total thiol, and disulfide levels were lower than the control group, and this difference was statistically significant. TDH parameters between surviving and non-surviving patients were similar at the sepsis diagnosis. However, significant differences found in native and total thiol levels at follow-up via repeated measurement analyses on days 3 and 7 in surviving and non-surviving sub-groups. <br />Conclusion: This study showed that impairment in dynamic TDH in adults with sepsis may be related to negative outcomes.  <br /> </p>}, number={1}, publisher={Cukurova University}