@article{article_638415, title={Preparation of Metformin HCl-loaded Chitosan Microspheres and In vitro Characterization Studies}, journal={Hacettepe University Journal of the Faculty of Pharmacy}, pages={74–86}, year={2015}, author={Mokhtare, Behzad and Cetin, Meltem and Ozakar, Rukiye Sevinc and Bayrakceken, Hatice}, keywords={Chitosan,DSC,FT-IR,Metformin HCl,Microsphere}, abstract={This study focuses on the preparation and in vitro characterisation of metformin HCl-loaded chitosan CS microspheres MS . Scanning Electron Microscopy SEM image shows that the microspheres have spherical shape. The particle size and encapsulation efficiency % value of the metformin HCl-loaded microspheres were found as 9.21±2.16 µm and 20.05±6.92%, respectively. The obtained low drug loading value is due to the high aqueous solubility of metformin HCl, and drug leakage from microspheres to the aqueous medium. In HCl pH 1.2 and phosphate buffer PB pH 6.8 mediums, about 22-36% of metformin HCL was released within 1 hour and about 89-98% of the loaded metformin HCl was released in 8 days. Furthermore, microspheres were characterised using FT-IR and DSC. These data demonstrate a potential for sustained release of metformin HCl by using prepared CS microspheres.}, number={1}, publisher={Hacettepe University}