@article{article_646939, title={Comparison of Effects of Administration of Oral or Topical Boron on Wound Healing and Oxidative Stress in Rats}, journal={Kocatepe Veterinary Journal}, volume={13}, pages={11–18}, year={2020}, DOI={10.30607/kvj.646939}, author={Konca, Meral and Korkmaz, Musa}, keywords={Antioxidant,boron,malondialdehyde,rat,wound healing}, abstract={<p class="MsoNormal" style="text-align:justify;"> <span lang="en-gb" style="font-size:11pt;font-family:Garamond, serif;" xml:lang="en-gb">The purpose of this study was to determine the effects
of boron on wound healing and further evaluate some antioxidant and oxidant
characteristics. A total of 32 adult male Wistar rats were divided into four
groups; control group, local boron (LB) group, oral boron (OB) group, and
oral+local boron (OLB) group. Under general anesthesia, a circular
full-thickness skin defect with a diameter of 1.5 cm was created on the dorsal
region of the rats. Boron (10 mg/kg) was administered per oral in OB group and
3% boric acid was administered topically in LB group, and 10 mg/kg boron was
administered per oral and 3% boric acid was applied topically in OLB group.
Control group did not receive any medication. In histopathological examination,
re-epithelialization, granulation tissue formation, collagen formation,
inflammatory cell formation, and neovascularization were found to be more superior
in LB and OLB groups as compared to the control and OB groups. Blood and wound
tissue MDA levels in OB and OLB groups were lower with respect to the control
and LB groups (p<0.05). In conclusion, oral administration of boron in
addition to topical treatment contributes the wound healing due to the
antioxidant property of boron <span style="color:#231F20;">in wound healing
process. </span> </span> </p> <p> </p>}, number={1}, publisher={Afyon Kocatepe University}, organization={Afyon Kocatepe Üniversitesi, Bilimsel Araştırma Projeleri Koordinasyon Birimi}