TY  - JOUR
T1  - Comparison of Effects of Administration of Oral or Topical Boron on Wound Healing and Oxidative Stress in Rats
TT  - Ratlarda Oral veya Topikal Olarak Uygulanan Borun Yara İyileşmesi ve Oksidatif Stres Üzerine Etkilerinin Karşılaştırılması
AU  - Korkmaz, Musa
AU  - Konca, Meral
PY  - 2020
DA  - March
Y2  - 2020
DO  - 10.30607/kvj.646939
JF  - Kocatepe Veterinary Journal
JO  - kvj
PB  - Afyon Kocatepe University
WT  - DergiPark
SN  - 1308-1594
SP  - 11
EP  - 18
VL  - 13
IS  - 1
LA  - en
AB  - The purpose of this study was to determine the effectsof boron on wound healing and further evaluate some antioxidant and oxidantcharacteristics. A total of 32 adult male Wistar rats were divided into fourgroups; control group, local boron (LB) group, oral boron (OB) group, andoral+local boron (OLB) group. Under general anesthesia, a circularfull-thickness skin defect with a diameter of 1.5 cm was created on the dorsalregion of the rats. Boron (10 mg/kg) was administered per oral in OB group and3% boric acid was administered topically in LB group, and 10 mg/kg boron wasadministered per oral and 3% boric acid was applied topically in OLB group.Control group did not receive any medication. In histopathological examination,re-epithelialization, granulation tissue formation, collagen formation,inflammatory cell formation, and neovascularization were found to be more superiorin LB and OLB groups as compared to the control and OB groups. Blood and woundtissue MDA levels in OB and OLB groups were lower with respect to the controland LB groups (p<0.05). In conclusion, oral administration of boron inaddition to topical treatment contributes the wound healing due to theantioxidant property of boron in wound healingprocess.
KW  - Antioxidant
KW  - boron
KW  - malondialdehyde
KW  - rat
KW  - wound healing
N2  - Bu çalışmanın amacı, borun yara iyileşmesi ve bazıantioksidan ve oksidan parametreler üzerine olan etkisinin belirlenmesidir.Çalışmada, toplam 32 adet erişkin erkekWistar ratı, kontrol grubu, lokal bor (LB) grubu, oral bor (OB) grubu veoral+lokal bor (OLB) grubu olmak üzereratgele dört gruba ayrıldı. Genelanestezi altında, ratların sırtbölgesinde 1,5 cm çapında dairesel tam kat bir deri defekti oluşturuldu. OBgrubunda bulunan ratlara oral olarak 10 mg/kg bor, LB grubunda bulunan ratlaratopikal % 3’lük borik asit, OLB grubundabulunan ratlara oral 10 mg/kg bor ile birlikte topikal olarak % 3’lük borikasit uygulandı. Kontrol grubuna ise herhangi bir ilaç uygulanmadı.Histopatalojik inceleme için yara dokusu örnekleri alındı. Histopatolojik olarak; repitelizasyon,granulasyon dokusu oluşumu, kollagen formasyonu, yangısal hücre oluşumu veneovaskülarizasyonun LB ve OLB gruplarında kontrol ve OB grubuna göre daha iyiolduğu belirlendi. OB ve OLB gruplarında kan ve yara dokusu MDA düzeylerininkontrol ve LB grubuna göre düşük olduğu belirlendi (p<0,05). Sonuç olarak; yara sağaltımında, lokal olarak borik asitkullanıma ek olarak antioksidan özelliklerinden dolayı oral bor kullanımınınyara iyileşmesine katkı sağladığı söylenebilir
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UR  - https://doi.org/10.30607/kvj.646939
L1  - https://dergipark.org.tr/en/download/article-file/946186
ER  -