TY - JOUR T1 - The relationship between platelet to lymphocyte ratio and the diurnal variation of hypertension TT - Platelet lenfosit oranı ve hipertansiyonun diürnal ritmi arasındaki ilişki AU - Çelebi, Savaş PY - 2020 DA - March DO - 10.18663/tjcl.648347 JF - Turkish Journal of Clinics and Laboratory JO - TJCL PB - DNT Ortadoğu Yayıncılık A.Ş. WT - DergiPark SN - 2149-8296 SP - 29 EP - 34 VL - 11 IS - 2 LA - en AB - Aim:Platelet to lymphocyte ratio (PLR) predicts worse outcome in cardiovasculardisease. However data is limitted about the role of PLR in the diurnalvariation of hypertension. In this study we evaluated the relationship betweenthe diurnal variation of hypertension and PLR. Material and Methods:The study included a total of 247 essential hypertensive patients. All patientsunderwent 24-hour ambulatory blood monitoring. Thereafter hypertensive patientswere divided into two groups: 64 dipper patients (30 female, mean age 53.8±12.9years) and 38 non-dipper patients (18 female, mean age 52.6±12.5years).Complete blood count and biochemistry were measured by standard methods. PLR was measured by dividing platelet countto lymphocyte count.Results:Non-dipper hypertensives had signifi cantly higher PLR levels than dippers(127.9±32.16 vs 103.4±10.67, p<0.001). There was a negatif correlationbetween percentage of sistolic and diastolic blood pressure fall and PLR. Conclusion:We demonstrated that PLR, an inexpensive and easily accessible biomarker, issignificantly higher in nondipper hypertensives than the dipper hypertensives. KW - Hypertension KW - non-dipper KW - dipper KW - platelet to lymphocyte ratio N2 - Amaç: Plateletlenfosit oranı (PLR) kardiyovasküler kötü sonlanımlar için öngördürücüdür.Ancak PLR’nın hipertansiyonun diürnal ritmindeki rolü ile ilgili verisınırlıdır. Biz bu çalışmada PLR ile hipertansiyonun diürnal ritmi arasındakiilişkiyi değerlendirmeyi amaçladık. Gereç ve Yöntemler: Çalışmayatoplamda 247 esansiyel hipertansiyon hastası dahil edildi. Tüm hastalara24-saat ambulatuar kan basıncı monitorizasyonu yapıldı. Takiben hastalar ikigruba ayrıldı: 64 dipper hasta (30 kadın, ortalama yaş 53.8±12.9) ve 38non-dipper hasta (18 kadın, ortalama yaş 52.6±12.5). Tam kan sayımı vebiyokimyasl değerlendirme standart metodlarla yapıldı. PLR platelet sayısınınlenfosit sayısına bölünmesiyle hesaplandı. Bulgular: Nondipperhipertansifler dipper hipertansiflere kıyasla daha yüksek PLR’ye sahipti(127.9±32.16’e 103.4±10.67, p<0.001). Sistolik ve diastolik kan basıncınındüşüş oranı ile PLR arasında negatif korelasyon mevcuttu.Sonuç: Ucuzve kolay ulaşılabilir bir biobelirteç olan PLR, nondipper hipertansiflerdedipper hipertansiflere kyasla daha yüksektir. CR - 1- O’ Brien E , Sheridan J , O ’ Malley K . Dippers and non-dippers. 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The relationship between neutrophil lymphocyte ratio and non-dipper hypertension. Clin Exp Hypertens 2013; 35: 570-73 UR - https://doi.org/10.18663/tjcl.648347 L1 - https://dergipark.org.tr/en/download/article-file/1015945 ER -