TY  - JOUR
T1  - Synthesis of New 3-Substiuted Quinazolin-4(3H)-one Compounds
AU  - Saad-aldeen, Rand Arshad
AU  - Al-ıraqı, Mohammed Ahmed
PY  - 2019
DA  - November
JF  - The Eurasia Proceedings of Science Technology Engineering and Mathematics
JO  - EPSTEM
PB  - ISRES Publishing
WT  - DergiPark
SN  - 2602-3199
SP  - 93
EP  - 98
VL  - 7
LA  - en
AB  - Quinazolin-4(3H)-one is a well-known heterocyclic compound with a unique place in medicinal chemistry, and it has drawn much attention due to its diversified biological activity. In this research we report the synthesis of some quinazolin-4-one derivatives containing acetylenic moiety. The quinazolin-4(3H)-one (1) was synthesized from the reaction of anthranilic acid with formamide under the conventional or microwave irradiation conditions. The quinazolin-4(3H)-one was converted to the corresponding 3-propargyl derivative (2) by its reaction with propargyl bromide in presence of potassium carbonate as a base and acetone as a solvent. The 3-propargyl quinazolin-4(3H)-one (2) was used as a precursor to synthesize new three series of heterocyclic compounds containing quinazolin-4(3H)-one moiety. Compound (2) was treated with ethyl magnesium bromide, then the resulted solution treated immediately with carbon disulfide and sublimed sulfur to synthesize 1,2-dithiol-3-thione compound (3). The 1,2,3-triazole compounds (5a-d) were synthesized by the reaction of compound (2) with alkyl azides (4a-d) according to Click reaction. The Mannich bases (6a-i) were synthesized via  Mannich reaction by reaction of the acetylenic compound (2) with secondary amines in presence of paraformaldehyde in1,4-dioxane as a solvent.  All the synthesized compounds were characterized by physical and spectral measurements.
KW  - Quinazolin-4-one
KW  - 2-dithiol-3-thione
KW  - 1
KW  - 2
KW  - 3-triazole
KW  - Click reaction
KW  - Mannich reaction
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UR  - https://dergipark.org.tr/en/pub/epstem/issue//653237
L1  - https://dergipark.org.tr/en/download/article-file/867626
ER  -