TY - JOUR T1 - Alkalen Reflü Gastritin İntragastrik pH ve Helicobacter Pylori Kolonizasyonu Üzerine Etkisi TT - The effect of alkaline reflux gasritis on intragastric pH and helicobacter pylori colonization AU - Kargın, Süleyman AU - Çetin Kargın, Nisa PY - 2020 DA - April Y2 - 2020 JF - Medical Journal of Western Black Sea JO - Med J West Black Sea PB - Zonguldak Bulent Ecevit University WT - DergiPark SN - 2822-4302 SP - 24 EP - 28 VL - 4 IS - 1 LA - tr AB - Amaç: Alkalen reflü gastrit ile Helicobacter pylori ilişkisi hâlen belirsizdir. Duodenogastrik reflüsonucu mideye kaçan safra ve pankres sıvılarının mide mukozasında kimyasal irritasyon ve pHdeğişikliklerine yol açtığı düşünülmektedir. Ancak intragastrik pH değişikliklerinin Helicobacterpylori üzerine etkisi ve duodenum içeriğinin intragastrik pH’ya etkisi bilinmemektedir. Bu çalışmadaalkalen reflü gastrit hastalarında intragastrik pH ile Helicobacter pylori varlığı arasındaki ilişkiaraştırılmıştır.Gereç ve Yöntemler: Çalışmaya gastroskopide alkalen reflü gastrit tespit edilen (n=30) ve kontrolgrubu için antral gastrit tanısı alan hastalar (n=35) dahil edildi. Tüm hastalardan gastroskopiesnasında mide içerisinden alınan sıvı örneğinden pH çalışıldı ve antrumdan alınan örnektenüreaz testi yapıldı.Bulgular: Alkalen reflü gastrit olgularında ortalama intragastrik pH kontrol grubu ile benzerdi(Sırasıyla 3,43±1,94, 3,2±2,02, p=0,504). Hem Alkalen reflü gastrit grubunda hem de kontrolgrubunda üreaz testi pozitifliği oranları benzerdi (p=0,461). Her iki grupta intragastrik pH’nın alkaliveya asidik olması üreaz testi pozitifliği ile ilişkili değildi.Sonuç: Alkalen reflü gastriti hastalarında da intragastrik pH’nın asidik olduğunu ve hemduodenogastrik safra reflüsünün hem de intragastrik pH değişiklikliklerinin Helicobacter pylorikolonozisyonu üzerine etkisi olmadığını düşünüyoruz. KW - Alkalen reflü KW - pH KW - KW - helikobakter pilori KW - gastrit N2 - Aim: The relationship between alkaline reflux gastritis and Helicobacter pylori remains unclear. Itis thought that bile and pancreatic fluids escaping into the stomach as a result of duodenogastricreflux cause chemical irritation and pH changes in the gastric mucosa. However, the effect ofintragastric pH changes on Helicobacter pylori and duodenal contents on intragastric pH are notknown. The aim of this study was to investigate the relationship between intragastric pH and thepresence of Helicobacter pylori in patients with alkaline reflux gastritis.Material and Methods: The patients who detected alkaline reflux gastritis (n = 30) and antral gastritis for the control group (n=35)by gastroscopy were included in the study. During gastroscopy of all patients pH was measured from the liquid sample taken fromthe stomach and rapid urease test was performed from the sample taken from the antrum.Results: The mean intragastric pH in cases with alkaline reflux gastritis was similar to the control group (3.43±1.94, 3.2±2.02,p=0.504, respectively). The rates of rapid urease test positivity were similar in both alkaline reflux gastritis and control groups(p=0.461). Intragastric pH was found to be alkaline or acidic was not associated with rapid urease test positivity in both groups.Conclusion: We believe that intragastric pH is acidic in patients with alkaline reflux gastritis too and both duodenogastric bile refluxand intragastric pH changes have no effect on Helicobacter pylori colonization CR - Referans1: 1. Fein M, et al. Fiberoptic technique for 24-hour bile reflux monitoring. Standards and normal values for gastric monitoring. Dig Dis Sci 1996; 41: 216- 225. CR - Referans2: Hyun JJ, et al. Correlation Between Bile Reflux Gastritis and Biliary Excreted Contrast Media in the Stomach. J Comput Assist Tomogr 2017; 41: 696–701. CR - Referans3: O’Connor HJ, et al. Campylobacter like organisms and reflux gastritis. J Clin Pathol 1986; 39: 531-534 CR - Referans4: Gad Elhak N, et al. Prevalence of Helicobacter pylori, gastric myoelectrical activity, gastric mucosal changes and dyspeptic symptoms before and after laparoscopic cholecystectomy. 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