@article{article_681282, title={The effects of hydrogen sulfide, carbon monoxide and nitric oxide on pentylenetetrazole-induced seizures in rats}, journal={Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi}, volume={15}, pages={1–6}, year={2020}, DOI={10.17517/ksutfd.681282}, author={Eroğlu, Ezgi and Çengelli Ünel, Çiğdem and Harmancı, Nuşin and Kaltuş, Zuhal and Kılıç, Cansu and Doğan, Hatice and Altınbaş, Rabiye and Erol, Kevser}, keywords={epilepsy, hydrogen sulfide, carbon monoxide, nitric oxide, seizures}, abstract={Objective: It is aimed to investigate the anti-convulsant effects of bioactive gas mediators hydrogen sulfide (H2S), carbon monoxide (CO) and nitric oxide (NO) in pentylenetetrazole-induced convulsions in rats.
Material Methods: Eighty male Wistar-Albino rats randomly divided into ten groups. Convulsions was induced by administering 60 mg/kg pentylentetrazole intraperitonally. Diazepam, NaHS, CORM-2, L-arginine and L-NAME were administred 60 minutes after pentylentetrazole. Seizure latency, seizure duration and seizure score were evaluated. Data were analyzed by the Kruskal Wallis test followed by posthoc analyses with Tukey. P <0.05 was considered statistically significant.
Results: Diazepam (2 mg/kg) extended the seizure latency and no significant difference was found in other groups. Diazepam (1 and 2 mg/kg) and NaHS (10 mg/kg) reduced seizure duration. NaHS (5 mg/kg), CORM-2 (5 and 10 mg/kg), L-arginine (30 and 100 mg/kg) and L-NAME (30 mg/kg) increased the seizure score significantly as compared to diazepam (1 and 2 mg/kg) groups.
Conclusion: NaHS (10 mg/kg) may be protective in pentylentetrazole-induced seizures.}, number={3}, publisher={Kahramanmaras Sutcu Imam University}, organization={Eskişehir Osmangazi Üniversitesi Tıp Fakültesi Bilimsel Araştırma Projeleri Komisyonu}