TY  - JOUR
T1  - Doğal ürün fukoksantin trendleri
TT  - Trends in a natural product fucoxanthin
AU  - İmamoğlu, Esra
AU  - Aslanbay, Bahar
PY  - 2021
DA  - March
DO  - 10.12714/egejfas.38.1.15
JF  - Ege Journal of Fisheries and Aquatic Sciences
JO  - EgeJFAS
PB  - Ege University
WT  - DergiPark
SN  - 2148-3140
SP  - 117
EP  - 124
VL  - 38
IS  - 1
LA  - tr
AB  - Fukoksantin, ksantofil grubuna ait karotenoidlerden biri olup yaygın olarak kahverengi deniz yosunlarında (makroalgler), diatomlarda ve birkaç mikroalg türünde bulunmaktadır. Fukoksantin pigmenti, alglerde klorofil ve protein ile birlikte kompleks bir yapı oluşturarak ışığın toplanmasında ve fotosentez merkezine gönderilmesinde önemli bir rol almaktadır. Son yıllarda yapılan araştırmalar sonucunda fukoksantinin hayvanlar üzerinde antiobezite, antidiyabet, antienflamatuvar, antikanser ve kardiyovasküler sistemi koruma gibi olumlu etkilere sahip olduğu görülmüştür. Bu nedenle kronik hastalıkların önlenmesinde ve tedavisinde fukoksantinin etken madde olarak kullanımına dair çalışmalar sürdürülmektedir. Ayrıca kozmetik, gıda ve yem sektörlerinde de fukoksantin bileşiğinin kullanım potansiyeli değerlendirilmektedir. Bu makalede fukoksantin karotenoidinin genel özelliklerinden, tarihsel gelişiminden ve mevcut kaynaklarından bahsedilmiş, hayvanlar üzerindeki potansiyel biyolojik aktiviteleri incelenmiş ve kullanım alanları ile birlikte piyasadaki durumu ortaya konmuştur.
KW  - Fukoksantin
KW  - Ksantofil
KW  - Karotenoid
KW  - Algal biyoteknoloji
KW  - Doğal ürün
N2  - Fucoxanthin is a xanthophyll pigment which occurs in marine brown seaweeds (macroalgae), diatoms and several microalgae species. It forms with chlorophyll a-c and several proteins, a major fucoxanthin-chlorophyll a/c complex, which transfers light energy to the photosynthesis center and plays a major role in light harvesting. Recent studies have reported that fucoxanthin has many physiological functions and biological effects, such as anti-obesity, antidiabetic, anti-inflammatory, anticancer and cardiovascular system protection.  Therefore, this pigment is highly preferred for the prevention and treatment of various chronic diseases. In addition, potential applications of high value fucoxanthin can be found in cosmetic, food and feed industries. In this review paper, the historical development, characteristic properties and possible sources of fucoxanthin are extensively described. The potential biological activities of fucoxanthin are also discussed. Finally, brief overview of common applications and market analysis of commercial fucoxanthin are also reported.
CR  - Abu-Ghannam, N. & Shannon, E. (2017). Seaweed Carotenoid, Fucoxanthin, as Functional Food, in V. K. Gupta, H. Treichel, V. Shapaval, L. Antonio de Oliveira and M. G. Tuohy (Eds.), Microbial Functional Foods and Nutraceuticals, John Wiley & Sons, Ltd, Chichester, UK.
CR  - Airanthi, M.K.W., Hosokawa, M. & Miyashita, K. (2011). Comparative antioxidant activity of edible japanese brown seaweeds. Journal of Food Science, 76(1), 104-111. DOI: 10.1111/j.1750-3841.2010.01915.x
CR  - Buschmann, A.H., Camus, C., Infante, J., Neori, A., Israel, A., Hernández-González, M.C., Pereda, S.V., Gomez-Pinchetti, J.L., Golberg, A., Tadmor-Shalev, N. & Critchley, A.T. (2017). Seaweed production: overview of the global state of exploitation, farming and emerging research activity. European Journal of  Phycology, 52(4): 391-406. DOI: 10.1080/09670262.2017.1365175
CR  - Conceição, D., Lopes, R.G., Derner, R.B., Cella, H., Barbosa do Carmo, A.P., D’Oca, M.G.M., Petersen, R., Passos, M.F., Vargas, V.J.C., Galli-Terasawa, L.V. & Kava, V. (2020). The effect of light intensity on the production and accumulation of pigments and fatty acids in Phaeodactylum tricornutum. Journal of Applied Phycology, 1-9 p. DOI: 10.1007/s10811-019-02001-6
CR  - Crupi, P., Toci, A.T., Mangini, S., Wrubl, F., Rodolfi, L., Tredici, M.R., Coletta, A. & Antonacci, D. (2013). Determination of fucoxanthin isomers in microalgae (Isochrysis sp.) by high-performance liquid chromatography coupled with diode-array detector multistage mass spectrometry coupled with positive electrospray ionization, Rapid Communications in Mass Spectrometry, 27(9), 1027-1035. DOI: 10.1002/rcm.6531
CR  - D’Orazio, N., Gemello, E., Gammone, M.A., Girolamo, M., Ficoneri, C. & Riccioni, G. (2012). Fucoxantin: A treasure from the sea. Marine Drugs, 10, 604-616. DOI: 10.3390/md10030604
CR  - Demirel, Z., Tok, R., İlter, I., Akyıl, S., Erdoğan, A., Koç, M., Kaymak Ertekin, F. & Conk Dalay, M. (2018). Biyokütle için mikroalg ve siyanobakteri’nin büyük ölçekli üretimi. Aquatic Research, 1(2): 64-76. DOI: 10.3153/AR18008
CR  - Dittami, S.M., Michel, G., Collen, J., Boyen, C. & Tonon, T. (2010). Chlorophyll-binding proteins revisited - a multigenic family of light-harvesting and stress proteins from a brown algal perspective. BMC Evolutionary Biology, 10: 365. DOI: 10.1186/1471-2148-10-365
CR  - Englert, G., Bjornland, T. & Liaaen-Jensen, S. (1990). 1D and 2D NMR study of some allenic carotenoids of the fucoxanthin series. Magnetic Resonance in Chemistry, 28: 519-528.
CR  - Gammone, M.A. & D’Orazio, N. (2015). Anti-obesity activity of the marine carotenoid fucoxanthin. Marine Drugs, 13, 2196-2214. DOI: 10.3390/md13042196
CR  - Gammone, M.A., Riccioni, G. & D’Orazio, N. (2015). Marine carotenoids against oxidative stress: Effects on human health. Marine Drugs, 13, 6226-6246. DOI: 10.3390/md13106226
CR  - Garama, D., Bremer, P. & Carne, A. (2012). Extraction and analysis of carotenoids from the New Zealand sea urchin Evechinus chloroticus gonads. Acta Biochimica Polonica, 59(1): 83-85.
CR  - Heo, S.J., Yoon, W.J., Kim, K.N., Ahn, G.N., Kang, S.M., Kang, D.H., Affan, A., Oh, C., Jung, W.K. & Jeon, Y.J. (2010) Evaluation of anti-inflammatory effect of fucoxanthin isolated from brown algae in lipopolysaccharide-stimulated RAW 264.7 macrophages. 
Food and Chemical Toxicology, 48: 2045–2051. DOI: 10.1016/j.fct.2010.05.003
CR  - Irvani, N., Hajiaghaee, R. & Zarekarizi, A.R. (2018). A review on biosynthesis, health benefits and extraction methods of fucoxanthin, particular marine carotenoids in algae. Journal of Medicinal Plants, 17(67).
CR  - Jaswir, I., Noviendri, D., Salleh, H.M., Taher, M., Miyashita, K. & Ramli, N. (2012). Analysis of fucoxanthin content and purification of all-trans-fucoxanthin from Turbinaria turbinata and Sargassum plagyophyllum by SiO2 open column chromatography and reversed phase-HPLC. Journal of Liqiud Chromatography & Related Technology, 36: 1340–1354. DOI: 10.1080/10826076.2012.691435
CR  - Joel, J. (2016). Global fucoxanthin market 2016 industry trends, sales, supply, demand, analysis and forecast to 2021, Analysis and Forecast. New York.
CR  - Joshi, S., Kumari, R. & Upasani, V.N. (2018). Applications of algae in cosmetics: An overview, International Journal of Innovvative Research in Science, Engineering and Technology, 7(2), 1269-1278. DOI: 10.15680/IJIRSET.2018.0702038
CR  - Kang, S.I., Shin, H.S., Kim, H.M., Yoon, S.A., Kang, S.W., Kim, J.H., Ko, H.C. & Kim SJ. (2012). Petalonia binghamiae extract and its constituent fucoxanthin ameliorate high-fat diet-induced obesity by activating AMP-activated protein kinase. Journal of Agricultural Food and Chemistry, 60: 3389−3395. DOI: 10.1021/jf2047652
CR  - Kim, S.M., Jung, Y.J., Kwon, O.H., Cha, K.H., Um, B.H., Chung, D. & Pan, C.H. (2012). A potential commercial source of fucoxanthin extracted from the microalga Phaeodactylum tricornutum. Applied Biochemistry and Biotechnology, 166: 1843–1855. DOI: 10.1007/s12010-012-9602-2
CR  - Kumar, S.R., Hosokawa, M. & Miyashita, K. (2013). Fucoxanthin: A marine carotenoid exerting anti-cancer effects by affecting multiple mechanisms. Marine Drugs, 11(12): 5130-5147. DOI: 10.3390/md11125130
CR  - Lu, X., Liu, B., He, Y., Guo, B., Sun, H. & Chen, F. (2019). Novel insights into mixotrophic cultivation of Nitzschia laevis for co-production of fucoxanthin and eicosapentaenoic acid. Bioresource Technology, 294, 122145. DOI: 10.1016/j.biortech.2019.122145
CR  - Maeda, H. (2015). Nutraceutical effects of fucoxanthin for obesity and diabetes therapy: A review, Journal of Oleo Sciences, 64(2), 125-132. DOI: 10.5650/jos.ess14226
CR  - Martin, L.J. (2015). Fucoxanthin and its metabolite fucoxanthinol in cancer prevention and treatment. Marine Drugs, 13(8): 4784-4798. DOI: 10.3390/md13084784
CR  - Matos, J., Cardoso, C., Gomes, A., Campos, A.M., Fale, P., Afonso, C. & Bandarra, N.M. (2019). Bioprospection of Isochrysis galbana and its potential as a nutraceutical. Food & Function, 10, 7333.	
DOI: 10.1039/c9fo01364d
CR  - Mise, T., Ueda, M. & Yasumoto, T. (2011) Production of fucoxanthin-rich powder from Cladosiphon okamuranus. Advance Journal of Food Science and Technology, 3(1): 73-76.
CR  - Mohamadnia, S., Tavakoli, O., Faramrzi M.A. & Shamsollahi, Z. (2020).  Production of fucoxanthin by the microalga Tisochrysis lutea: A review of recent developments. Aquaculture, 516, 734637.	
DOI: 10.1016/j.aquaculture.2019.734637
CR  - Nahar, M., Hasan, W., Rajak, R. & Jat, D. (2017). Oxidative Stress And Antioxidants: An Overview, International Journal of Advanced Research and Review, 2(9), 110-119.
CR  - Oryza Oil & Fat Chemical Co., Ltd. (2008). Fucoxanthin dietary ingredient for prevention of metabolic syndrome, antioxidation and cosmetics, Product Cataloug. Alıntılanma adresi: http://www.oryza.co.jp/pdf/english/Fucoxanthin_1.0.pdf (02.12.2019)
CR  - Páduaa, D., Rochaa, E., Gargiuloa, D. & Ramosa, A.A. (2015). Bioactive compounds from brown seaweeds: Phloroglucinol, fucoxanthin and fucoidan as promising therapeutic agents against breast cancer. Phytochemistry Letters, 14, 91–98. DOI: 10.1016/j.phytol.2015.09.007
CR  - Peng, J., Yuan, J.P., Wu, C.F. & Wang, J.H. (2011). Fucoxanthin, a marine carotenoid present in brown seaweeds and diatoms: Metabolism and bioactivities relevant to human health. Marine Drugs, 9(10): 1806-1828. DOI: 10.3390/md9101806
CR  - Perez-Lopez, P., Balboa, E.M., Gonzalez-Garcia, S., Dominguez, H., Feijoo, G. & Moreira, T. (2014). Comparative environmental assessment of valorization strategies of the invasive macroalgae Sargassum muticum. Bioresource Technology, 161, 137–148. DOI: 10.1016/j.biortech.2014.03.013
CR  - Prabhasankar, P., Bhaskar, N., Hirose, A., Stephen, N., Growda, L.R., Hosokawa, M. & Miyashita, K. (2009). Edible Japanese seaweed, wakame (Undaria pinnatifida) as an ingredient in pasta: Chemical, functional and structural evaluation. Food Chemistry, 115, 501–508 p. DOI: 10.1016/j.foodchem.2008.12.047
CR  - Quitain, A.T., Kai, T., Sasaki, M. & Goto, M. (2013). Supercritical Carbon dioxide extraction of fucoxanthin from Undaria pinnatifida. Journal of Agricultural Food and Chemistry, 61, 5792−5797.	
DOI: 10.1021/jf400740p
CR  - Rajauria, G., Foley, B. & Abu-Ghannama, N. (2017). Characterization of dietary fucoxanthin from Himanthalia elongata brown seaweed. Food Research International, 99(3): 995-1001. DOI: 10.1016/j.foodres.2016.09.023
CR  - Raposo, M.F.J., Morais, A.M.M.B. & Morais, R.M.S.C. (2015). Carotenoids from marine microalgae: A valuable natural source for the prevention of chronic diseases. Marine Drugs, 13, 5128-5155.	
DOI: 10.3390/md13085128
CR  - Sahin, M.S., Khazi, M.I., Demirel, Z. & Conk Dalay, M. (2019). Variation in growth, fucoxanthin, fatty acids profile and lipid content of marine diatoms Nitzschia sp. and Nanofrustulum shiloi in response to nitrogen and iron. Biocatalysis and Agricultural Biotechnology, 19, 390-398. DOI: 10.1016/j.bcab.2018.12.023
CR  - Sakai, S., Sugawara, T. & Hirata, T. (2011). Inhibitory effect of dietary carotenoids on dinitrofluorobenzene-induced contact hypersensitivity in mice. Bioscience, Biotechnology and Biochemistry, 75, 1013 – 1015. DOI: 10.1271/bbb.110104
CR  - Sangeetha, R.K., Bhaskar, N., Divakar, S. & Baskaran, V. (2010). Bioavailability and metabolism of fucoxanthin in rats: structural characterization of metabolites by LC-MS (APCI). Molecular and Cellular Biochemistry, 333: 299–310. DOI: 10.1007/s11010-009-0231-1
CR  - Susanto, E., Fahmi, A.S., Abeb, M., Hosokawa, M. & Miyashita, K. (2016). Lipids, fatty acids, and fucoxanthin content from temperate and tropical brown seaweeds. Aquatic Procedia, 7, 66 – 75.	
DOI: 10.1016/j.aqpro.2016.07.009
CR  - Takahashi, K., Hosokawa, M., Kasajima, H., Hatanaka, K., Kudo, K., Shimoyama, N. & Miyashita, K. (2015). Anticancer effects of fucoxanthin and fucoxanthinol on colorectal cancer cell lines and colorectal cancer tissues. Oncology Letters, 10, 1463-1467. DOI: 10.3892/ol.2015.3380
CR  - Urikura, I., Sugawara, T. & Hirata, T. (2011). Protective effect of fucoxanthin against UVB induced skin photoaging in hairless mice. Bioscience, Biotechnology and Biochemistry, 75(4), 757-760.	
DOI: 10.1271/bbb.110040
CR  - Wang, H., Zhang, Y., Chen, L., Cheng, W. & Liu, T. (2018). Combined production of fucoxanthin and EPA from two diatom strains Phaeodactylum tricornutum and Cylindrotheca fusiformis cultures. Bioprocess and Biosystem Engineering, 41: 1061. DOI: 10.1007/s00449-018-1935-y
CR  - Xia, S., Wang, K., Wan, L., Li, A., Hu, Q. & Zhang, C. (2013).  Production, Characterization, and Antioxidant Activity of Fucoxanthin from the Marine Diatom Odontella aurita. Marine Drugs, 11, 2667-2681.	
DOI: 10.3390/md11072667
CR  - Zarekarizi, A., Hoffmann, L. & Burritt, D. (2019). Approaches for the sustainable production of fucoxanthin, a xanthophyll with potential health benefits. Journal of Applied Phycology, 31(1), 281-299.	
DOI: https://doi.org/10.1007/s10811-018-1558-3
CR  - Zhang, H., Tang, Y., Zhang, Y., Zhang, S., Qu, J., Wang, X., Kong, R., Han, C. & Liu, Z. (2015). Fucoxanthin: A promising medicinal and nutritional ingredient. Evidence-Based Complementary Alternative Medicine, 2015, 723515. DOI: 10.1155/2015/723515
CR  - Zhao, D., Kim, S., Pan, C. & Chung, D. (2014). Effects of heating, aerial exposure and illumination on stability of fucoxanthin in canola oil. Food Chemistry, 145, 505–513. DOI: 10.1016/j.foodchem.2013.08.045
UR  - https://doi.org/10.12714/egejfas.38.1.15
L1  - https://dergipark.org.tr/en/download/article-file/1156435
ER  -