@article{article_695218, title={Evaluation of Anti-CCP and RF in pre-diagnosed Patient Serums of Rheumatoid Arthritis}, journal={Journal of Immunology and Clinical Microbiology}, volume={6}, pages={1–6}, year={2021}, author={Kaya, Selçuk and Karabey, Mehmet and Aksoy Gökmen, Ayşegül and Kabadayı, Gökhan}, keywords={Anti CCP, , Romatoid artrit (RA), , RF, , CRP, , sedimentasyon}, abstract={Rheumatoid arthritis (RA) is a chronic and inflammatory disease characterized by inflammation, pain and muscle weakness in the tendon sheath and joints. In this study, it was aimed to evaluate the relationship of anti-CCP and RF values with each other and with other diagnostic assisting test results (CRP, WBC, PLT, and Sedimentation) in patients who have been pre-diagnosed with rheumatoid arthritis in Izmir Katip Çelebi University Atatürk Training and Research Hospital Medical Microbiology Laboratory. A total of 5399 patients who have pre-diagnosed as RA between January 2017 and August 2018 were included in the study. Anti-CCP levels were investigated with the Enzyme Immunoassay method by using the ORGENTEC Diagnostica GMBH kit via the Alegria instrument. The RF levels were investigated with the Turbidimetric method by Abbott Architect C16000 instrument according to the manufacturer’s instructions. Anti-CCP was positive in 498 (9.2%) patients and RF positive in 4213 (78%) patients. RF was found to be negative in 43 (8.6%) of 498 patients identified as anti-CCP positive. In addition, anti-CCP was negative in 3758 (89.2%) of 4213 patients who were identified as RF positive. A significant correlation was found between anti-CCP values and RF, PLT, and sedimentation values, and between RF values and WBC, PLT and sedimentation values. In addition, Anti-CCP can be used to distinguish RA from other RF positive arthritis forms due to its high specificity. In our study, RF was determined as negative in some of the patients diagnosed with RA, while anti-CCP was determined as positive. Therefore, it helps to diagnose RA in patients with seronegative RA. While the increase in the sedimentation values in RA patients supports the diagnosis, the benefit of the CRP test was found to be limited.}, number={1}, publisher={Erkan YULA}