@article{article_71546, title={Increased Sister Chromatid Exchanges in Patients with Gastrointestinal Cancers and in their First-Degree Relatives}, journal={European Journal of General Medicine}, volume={11}, pages={94–98}, year={2014}, DOI={10.15197/sabad.1.11.46}, author={Turgut, Taner and Yaşar, Mehmet and Yaykaşlı, Kürşat Oğuz and Ertaş, Ertuğrul and Sılan, Fatma}, keywords={Sister chromatid exchange, chromosomal instability, gastrointestinal cancer}, abstract={Gastrointestinal Cancers (GICs) are the most important causes of mortality and morbidity in industrialized world. Sister chromatid exchange (SCE), as an index of chromosomal instability, involves cancer. The aim of this study is to determine whether SCE frequency is a heritable factor for GIC or not. The study groups consisted of 15 gastrointestinal carcinoma patients, 13 patient relatives and 15 healthy subjects as the control group. After collection of 2 ml peripheral blood, lymphocytes were cultured for 3 days and sister chromatid exchange (SCE), mitotic index, and replication index were analyzed. SCE was significantly increased (p}, number={2}, publisher={Sağlık Bilimleri Araştırmaları Derneği}