TY - JOUR T1 - CLINICAL SIGNIFICANCE OF PREOPERATIVE SERUM IL-6 LEVELS IN GASTRIC CARCINOMA WITH LYMPH NODE METASTASIS TT - CLINICAL SIGNIFICANCE OF PREOPERATIVE SERUM IL-6 LEVELS IN GASTRIC CARCINOMA WITH LYMPH NODE METASTASIS AU - Kemik, Ahu Sarbay AU - Kemik, Ozgür AU - Hasırcı, İsmail AU - Dulger, Ahmet Cumhur AU - Adas, Mine AU - Purisa, Sevim AU - Tuzun, Sefa PY - 2010 DA - December JF - European Journal of General Medicine PB - Sağlık Bilimleri Araştırmaları Derneği WT - DergiPark SN - 1304-3889 SP - 410 EP - 413 VL - 7 IS - 4 LA - en CR - Stacker SA, Caesar C, Baldwin ME, et al. VEGF-D promotes the metastatic spread of tumor cells via the lymphatics. Nat Med 2001;7:186-91. CR - Mandriota SJ, Jussila L, Jeltsch M, et al. vascular endothelial growth factor-C mediated lymphangiogenesis promotes tumor metastasis. EMBO J 2001;20:672-82. CR - Skobe M, Hawighorst T, Jackson DG, et al. Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis. Nat Med 2001;7:192-8. CR - Choi JH, Oh YH, Park YW, Baik HK, Lee YY, Kim S. Correlation of VEGF-D expression and VEGFR3-positive vessel density with lymph node metastasis in gastric carcinoma. J Korean Med Sci 2008 23(4):592-7. CR - Cohen T, Nahari D, Cerem LW, Neufeld G, Levi BZ. IL-6 induces the expression of vascular endothelial growth factor. J Biol Chem 1996;27(2):736-41. CR - Thong-Ngam D, Tangkijvanich P, Lerknimitr R, Mahachi V, Theamboonlers A, Poorawan Y. Diagnostic role of serum interleukin-18 in gastric cancer patients. World J Gastroenterology 2006;12(28):4473-7. CR - To KF, Chan MW, Leung WK, et al. Constitutional activation of IL-6-mediated JAK/STAT pathway through hypermethylation of SOCS-1 in human gastric cancer cell line. Br J Cancer 2004;91(7):1335-41. CR - Watanabe S, Mu W, Kahn A, et al. Role of JAK/STAT pathway in IL-6-induced activation of vascular endothelial smooth muscle cells. Am J Nephrol 2004;24(4):387-92. CR - Rawlings JS, Rosler KM, Harrison DA. The JAK/STAT signaling pathway. J Cell Sci 2004;117 (Pt 8):1281-3. CR - Heinrich PC, Behrmann I, Haan S, et al. Principles of IL6-type cytokine signaling and its regulation. Biochem J 2003;374(Pt 1):1-20. CR - Lin MT, Lin BR, Chang CC, et al. IL-6 induces AGS gastric cancer cell invasion via activation of the c-Src/RhoA/Rock signaling pathway. Int J Cancer 2007;120(12):2600-8. CR - Liao WC, Lin JT, Wu CY, et al. Serum IL-6 level but not genotype predicts survival after resection in stages II and III gastric carcinoma. Clin Cancer Res 2008;14(2):428-34. CR - Ashizawa T, Okada R, Suzuki Y, et al. Clinical significance of IL-6 in the spread of gastric cancer: role of IL-6 as a prognostic factor. Gastric Cancer 2008;8(2):124-31. CR - Chung YC, Chang YF. Serum IL-6 levels reflect the disease status of colorectal cancer. J Surg Oncol 2003;83(4):2226. CR - Huang SP, Wu MS, Wang HP, Yang CS, Kuo ML, Lin JT. Correlation between serum levels of IL-6 and VEGf in gastric carcinoma. J Gastroenterol Hepatol 2002;17(11):11659. CR - Nikiteas NI, Tzanakis N, Gazouli M, et al. Serum IL-6, TNFalpha and CRP levels in Greek colorectal cancer patients: prognostic implications. World J Gastroenterol 2005; 11(11):1639-43. UR - https://dergipark.org.tr/en/pub/ejgm/issue//71871 L1 - https://dergipark.org.tr/en/download/article-file/61532 ER -