@article{article_72063, title={Investigation Of Anti-Inflammatory Activity Of Bergamot Oil}, journal={European Journal of General Medicine}, volume={4}, pages={176–179}, year={2007}, author={Karaca, Mehmet and Özbek, Hanefi and Him, Aydın and Tütüncü, Mehmet and Akkan, Hasan Altan and Kaplanoğlu, Veysel}, keywords={Citrus aurantium subsp. bergamia, Bergamot oil, anti-inflammatory activity, carrageenan-oedema}, abstract={Aim: Essential oil of Bergamot (BO) was investigated for anti-inflammatory activity using carrageenan-induced rat paw oedema test. Methods: For the anti-inflammatory activity measurement six different groups were established and BO was administered in three different doses: 0.025, 0.05 and 0.10 mL/kg. Indomethacin was used as a reference agent. Results: It was found that reduction in the inflammation was 95.70% with indomethacin, 27.56% with 0.025 mL/kg BO, 30.77% with 0.05 mL/kg BO and 63.39% with 0.10 mL/kg BO. Indomethacin showed the strongest anti-inflammatory activity among the drugs used. The strongest anti-inflammatory activity of BO was seen with 0.10 mL/kg dosage. Median effective dose (ED50) value of BO was found to be 0.079 mL/kg. Conclusion: The results showed that BO posseses promising anti-inflammatory effect}, number={4}, publisher={Sağlık Bilimleri Araştırmaları Derneği}