@article{article_72149, title={Mechanism of Action of Jatropha Gossypifolia Stem Latex As a Haemostatic Agent}, journal={European Journal of General Medicine}, volume={2}, pages={140–143}, year={2005}, author={Oduola, Taofeeq and Adeosun, Ganiyu Oyebola and Oduola, Tesleem Aderemi and Ovie, Godwin}, keywords={Jatropha gossypifolia, haemostatic agent, mechanism}, abstract={Aim: Jatropha gossypifolia belongs to the family “Euphorbiacea”. The coagulant activity and the mechanism of action of Jatropha gossypifolia stem latex as a haemostatic agent were investigated. Methods: The mechanism of action was investigated using doubling dilution technique by mixing neat (undiluted) and serial dilutions of the latex with 30% bovine albumin. Results: The results of whole blood clotting time using Lee and White method and bleeding time using Ivy\’s method were significantly reduced (P < 0.05) when stem latex was introduced than when the tests were performed without stem latex. This means that the stem latex possesses procoagulant activity. Conclusion: The result of this test showed that precipitation of coagulant factors is the mechanism of action of its haemostatic activity. Keywords: Jatropha gossypifolia, haemostatic agent, mechanism.}, number={4}, publisher={Sağlık Bilimleri Araştırmaları Derneği}