@article{article_725147, title={Biological Evaluation of Curcumin As a Natural RANKL Inhibitor in Osteosarcoma}, journal={Türk Doğa ve Fen Dergisi}, volume={9}, pages={1–5}, year={2020}, DOI={10.46810/tdfd.725147}, author={Özgür, Aykut}, keywords={Osteosarcoma,Curcumin,RANKL,Saos-2}, abstract={Osteosarcoma is an important health problem among children and teenagers. Metastases is observed in about twenty percent of osteosarcoma patients. RANK/RANKL/OPG signaling pathway is involved in formation of osteosarcoma and its metastases. Especially, the overexpression of RANKL is related to osteoclast and osteosarcoma formation. Therefore, inhibition of RANKL activity has been significant treatment method of osteosarcoma. In this study, curcumin was evaluated as RANKL inhibitor in osteosarcoma cells. In this context, anti-proliferative and anti-invasive properties of the curcumin were determined with in-vitro and computational assays in Saos-2 cell line. Obtained results showed that curcumin may has a potential for treatment of osteosarcoma and its metastases.}, number={1}, publisher={Bingol University}, organization={Tokat Gaziosmanpaşa Üniversitesi}