@article{article_736331, title={MANUFACTURE OF SPHERICAL GRANULES OF ISOSORBIDE DINITRATE WITH MODIFIED RELEASE}, journal={Journal of Faculty of Pharmacy of Ankara University}, volume={44}, pages={481–493}, year={2020}, DOI={10.33483/jfpau.736331}, author={Olıınykov, Dmytro and Kaplaushenko, Andrii and Trehub, Svetlana and Kovalyova, Katerina}, keywords={Isosorbide dinitrate, release profile, spherical matrix pellets}, abstract={<div style="text-align:justify;"> <span style="font-size:12px;"> <b>Objective: </b> This study was aimed to obtain spherical matrix pellets of isosorbide dinitrate with different dissolution kinetics to create a multidosage medicinal form with controlled release of the active substance. </span> </div> <div style="text-align:justify;"> <span style="font-size:12px;"> <b>Material and Method: </b>Spherical matrix granules were obtained by extrusion-spherinization and coated with different amounts of polymer shell. Dissolution profiles of the obtained spheroids were compared with reference drug tablets. </span> </div> <div style="text-align:justify;"> <span style="font-size:12px;"> <b>Result and Discussion: </b>The results showed that the combination of spherical granules provides an isosorbide dinitrate release profile similar to the dissolution of Cardicet Retard tablets. The target dissolution profile is achieved using a combination of uncoated spherical granules and spheroids with a 10% film coating. The similarity coefficient (f2) is 73.6. </span> </div>}, number={3}, publisher={Ankara University}, organization={RPF "MICROKHIM", Ukraine}