@article{article_738743, title={Synthesis and Anticancer Activities of Water Soluble Schiff Base Metal Complexes}, journal={Adıyaman University Journal of Science}, volume={10}, pages={441–454}, year={2020}, DOI={10.37094/adyujsci.738743}, author={Saygıdeğer Demir, Burcu and Gönül, İlyas and Gümüşgöz Çelik, Gizem and İpekbayrak, Seda and Saygideger, Yasemin}, keywords={Schiff base, Metal complexes, Lung cancer, Cell culture}, abstract={In this study, we synthesized the water-soluble Schiff Base containing S, O, N heteroatoms by the condensation reaction from 4-amino-3-hydroxynaphthalene-1-sulfonic acid and 2- hydroxy-3-methoxybenzaldehyde. In addition, Cu (II), Zn (II) and Ni (II) complexes of the ligand were synthesized and characterized by elemental analysis, magnetic susceptibility and spectroscopic techniques such as FT-IR, H-NMR and C-NMR. The anticancer activities of ligand and its three metal complexes on A549 lung cancer cell lines were evaluated. Cell viability experiments revealed that Ligand (L) and nickel (II) complex (L-Ni) did not able to inhibit A549 cell proliferation while L-Cu and L-Zn had 12 and 80 μM of IC50 values respectively. These last two complexes also induced apoptosis and suppressed cell migration on A549 cells. <br />}, number={2}, publisher={Adıyaman University}