@article{article_751363, title={The prognostic Evaluation of West Syndrome Patients: A Retrospective Observational Study}, journal={Konuralp Medical Journal}, volume={13}, pages={149–155}, year={2021}, DOI={10.18521/ktd.751363}, author={Türay, Sevim and Hancı, Fatma and Dilek, Mustafa and Kabakuş, Nimet}, keywords={West syndrome, ACTH therapy, spasm, neurodevelopmental delay, prognosis}, abstract={<p>Objective: To determine neurodevelopmental and seizure prognoses in our patients with West syndrome receiving adrenocorticotropic hormone (ACTH) therapy, and to identify the factors affecting these. </p> <p>Materials methods:
We determined the demographic factors, previous seizure histories, ACTH use and response times, and etiological factors of 34 patients diagnosed with West syndrome in our clinic at 3-24 months and receiving ACTH therapy. We also investigated their neurological development and its effect on seizure prognosis. </p> <p>Results: We found a significant relationship between patients experiencing seizures before diagnosis and subsequent seizure prognosis. We also found a later response to ACTH and poorer neurodevelopmental and seizure prognoses in patients with symptomatic etiologies. Global developmental delay was determined in 76% of all cases, and seizures persisted despite antiepileptic drugs in 62%. </p> <p>Conclusions: Symptomatic etiological factors in West syndrome adversely affect the neurodevelopmental process and subsequent seizure prognosis. </p>}, number={1}, publisher={Duzce University}