@article{article_763496, title={Comparison the Effect of Different Ratios of Ketamine and Propofol (Ketofol) Admixture on Anesthesia Induction in New Zealand White Rabbits}, journal={Atatürk Üniversitesi Veteriner Bilimleri Dergisi}, volume={15}, pages={251–256}, year={2020}, DOI={10.17094/ataunivbd.763496}, author={Yanmaz, Latif Emrah and Doğan, Elif and Şenocak, Mümin Gökhan and Ersöz, Uğur and Okur, Sıtkıcan}, keywords={Anaesthesia, Ketamine, propofol, rabbit}, abstract={<div style="text-align:justify;"> <span style="font-size:.9em;">This study was aimed to detect the effects of anesthesia induction with ketamine-propofol (ketofol) admixture in rabbits. Eight, healthy New Zealand white rabbits were randomly received ketofol admixture at the ratio of 1:1, 1:2, and 1:3 with one-week intervals. The length of surgical anesthesia was continuously evaluated until the presence of pedal withdrawal and ear-pinch reflexes. The recovery was assessed by the existence of the righting reflex. The heart rate and respiratory frequency values were recorded at pre-treatment, induction, and two minutes intervals until 20 minutes. There was no statistically significant difference between groups with respect to the ear-pinch reflex and pedal withdrawal reflex. The righting reflex returned earliest at the ratio of 1:1 (8.88 ± 0.63 minutes) which was significantly shorter than the ratio of 1:2 (10.50 ± 0.94 minutes) or 1:3 (13.62 ± 1.93 minutes). The animals receiving ketofol at the ratio of 1:3 had significantly lower respiratory frequency compared to 1:2 and 1:1 ratios at 0, 2, 4, 6, 8, and 12 minutes. The ketofol admixture at the ratio of 1:1 has less respiratory depression effects, and higher doses of propofol in ketofol admixture can be associated with anesthetic complication. </span> </div>}, number={3}, publisher={Ataturk University}, organization={Ataturk University Scientific Research Projects}