TY - JOUR T1 - Nazal polipoziste histopatolojik bulgular ile klinik ölçütler ile arasındaki ilişki TT - The correlation of clinical measures with the histopathological findings in nasal polyposis AU - Kule, Zeynep Altın AU - Deveci, Hande Senem AU - Kule, Mustafa AU - Habeşoğlu, Tülay Erden AU - Somay, Adnan AU - Gürsel, Ali Okan PY - 2015 DA - March DO - 10.2399/jmu.2015001002 JF - ENT Updates PB - AVES YAYINCILIK WT - DergiPark SN - 2149-7109 SP - 1 EP - 8 VL - 5 IS - 1 LA - tr AB - Amaç: Bu çalışmada nazal polipozisli hastalarda histopatolojik bulguların detaylı olarak tanımlanarak bu bulguların hastalığın şiddeti ve astım, alerji ve kan eozinofil düzeyi gibi bazı eşlik eden faktörlerle ilişkisinin araştırılması amaçlanmıştır. Yöntem: Çalışmada 2007-2011 yılları arasında endoskopik sinüs cerrahisi uygulanan yetmiş-yedi nazal polipozisli hastanın (52 erkek, 25 kadın; yaş ortalaması: 46.99±13.27) verileri incelenmiştir. Yapılan retrospektif değerlendirmede endoskopik skorları, Lund-Mackay bilgisayarlı tomografi skorları, nazal obstrüksiyon semptom değerlendirme skalaları, alerji ve astım varlığı ve kan eozinofil düzeyleri kaydedilmiştir. Bu veriler histopatolojik bulgularla (bazal membran kalınlığı, goblet hücre hiperplazisi, subepitelyal ödem, submukozal gland formasyonu, eozinofilik infiltrasyon, lenfositik infiltrasyon ve polimorfonükleer infiltrasyon) karşılaştırılmıştır. Bulgular: Bulgular değerlendirildiğinde eozinofil infiltrasyonu ve kan eozinofil düzeyleri arasında istatistiksel açıdan anlamlı bir ilişki saptanmıştır (p KW - Nazal polipozis KW - histopatoloji KW - eozinofili KW - şiddet KW - korelasyon N2 - Objective: The aim of this study was to outline the histopathological findings of nasal polyposis and to investigate whether these findings were associated with the severity of the disease and co-existing morbidities as well as hematological parameters. Methods: Seventy-seven nasal polyposis (52 male, 25 female; mean age: 46.99±13.27 years) patients who underwent endoscopic sinus surgery between 2007 and 2011 were included in the study. Data was extracted from medical files and endoscopy scores, and Lund-Mackay Computed Tomography scores, Nasal Obstruction Symptom Evaluation (NOSE) scales, presence of allergy and asthma, and blood eosinophil levels were noted. Correlation of this data with histopathological findings (such as basement membrane thickness, goblet cell hyperplasia, subepithelial edema, submucous gland formation, eosinophilic infiltration, lymphocytic infiltration and polymorphonuclear leukocyte infiltration) was analyzed. Results: Analysis of our findings yielded that the only statistically significant finding was the correlation of eosinophilic infiltration with the blood eosinophil level (p CR - Bachert C, Hörmann K, Mösges R, et al. An update on the diag- nosis and treatment of sinusitis and nasal polyposis. 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CR - Please cite this article as: Altın Kule Z, Deveci HS, Kule M, Erden Habeflo¤lu T, Somay A, Gürsel AO. The correlation of clinical measures with the CR - histopathological findings in nasal polyposis. ENT Updates 2015;5(1):1–8. UR - https://doi.org/10.2399/jmu.2015001002 L1 - https://dergipark.org.tr/en/download/article-file/65325 ER -