@article{article_782874, title={Evaluating Effects of Black Carrot Extract on Testicular Carboxylesterase Activity and Oxidative Stress Parameters in Rats Exposed to Bisphenol A}, journal={Adıyaman University Journal of Science}, volume={11}, pages={73–86}, year={2021}, DOI={10.37094/adyujsci.782874}, author={Özkaya, Ahmet and Şahin, Zafer and Şahin, Yunus and Bulmuş, Özgür and Uçkun, Miraç and Yoloğlu, Ertan}, keywords={Bisphenol A, Black carrot, Testis, Carboxylesterase, Oxidative stress, Rat}, abstract={We aimed to evaluate the effects of black carrot extract on testicular carboxylesterase (Ces) activity, malondialdehyde (MDA), glutathione S-transferases (GST) and reduced glutathione (GSH) in male rats exposed to bisphenol A (BPA). Adult Wistar albino male rats were divided into 4 groups as follows (n = 7/group): control, BPA, black carrot and BPA+Black carrot. Testicular Ces, MDA, GST and reduced GSH were analyzed by using a spectrophotometer system. Testicular Ces activity was significantly lower only in the BPA group than the control group (p < 0.001). Testicular MDA concentrations were higher only in the BPA group compared with the control group (p < 0.001). Reduced GSH level was higher in the black carrot and BPA+Black carrot groups than the control group (p < 0.05). GST activity was lower in the BPA group in comparison to the control group (p < 0.05). In the black carrot and BPA+Black carrot groups, the GST activities were higher than the control group (p < 0.001). Our results showed BPA suppresses testicular detoxification activity and increases lipid peroxidation in rats. We observed that black carrot extract has a beneficial effect on the toxic and oxidative stress-related parameters caused by BPA exposure. <br />}, number={1}, publisher={Adıyaman University}