TY  - JOUR
T1  - ÇÖLYAK HASTALIĞINDA MİKRO BESİN ÖGESİ EKSİKLİKLERİ VE BESLENME ÖNERİLERİ
TT  - MICRONUTRIENTS DEFICIENCIES AND NUTRITIONAL RECOMMENDATIONS IN CELIAC DISEASE
AU  - Tunçer, Esra
AU  - Yabancı Ayhan, Nurcan
PY  - 2021
DA  - April
Y2  - 2021
DO  - 10.46413/boneyusbad.807225
JF  - Bandırma Onyedi Eylül Üniversitesi Sağlık Bilimleri ve Araştırmaları Dergisi
PB  - Bandirma Onyedi Eylul University
WT  - DergiPark
SN  - 2687-2145
SP  - 29
EP  - 38
VL  - 3
IS  - 1
LA  - tr
AB  - Çölyak; genetik yatkınlığı olan bireylerde glutenin tüketilmesiyle tetiklenen, ince bağırsaklarda inflamasyona neden olan sistemik, immün aracılı bir hastalıktır ve tedavisi glutensiz diyettir. Malabsorbsiyonlar ve glutensiz diyetin bazı besin ögelerini (magnezyum, tiamin, riboflavin, niasin vb.) yeterli miktarda içermemesi nedenleriyle çölyak hastalığında besin ögesi eksiklikleri görülebilir. Bu derlemenin amacı, çölyak hastalığında mikro besin ögesi eksiklerini literatür kapsamında incelemektir.Çölyak tanısı sırasında sık görülen mikro besin ögesi eksikleri demir, kalsiyum, magnezyum, D vitamini, çinko, folat, niasin, B12 vitamini, riboflavin şeklinde sayılmaktadır.Sonuçta, çölyak hastalığında vitamin-mineral eksikliklerinin tedavisi için glutensiz diyete uyum ile optimal beslenmenin sağlanmasının gerekliliği görülmektedir. Ayrıca, gereken durumlarda hekim kontrolünde besin takviyesi alınmalıdır.
KW  - Çölyak hastalığı
KW  - Beslenme bilimi
KW  - Mineraller
KW  - Vitaminler
N2  - Celiac disease, which is triggered by consuming gluten in individuals with a genetic predisposition, is a systemic, immune-mediated disease, causing inflammation in the small intestine, and its treatment is the gluten-free diet. Nutritional deficiencies can be observed in celiac disease due to malabsorption, and a gluten-free diet may not contain enough nutrients (magnesium, thiamine, riboflavin, niacin, etc.). This review aims to evaluate micronutrient deficiencies in celiac disease in the context of the literature.Micronutrient deficiencies frequently seen during the diagnosis of celiac are stated as iron, calcium, magnesium, vitamin D, zinc, folate, niacin, vitamin B12, riboflavin deficiencies.In conclusion, it is necessary to adherence to a gluten-free diet and to ensure optimal nutrition for the treatment of vitamin-mineral deficiencies in celiac disease. In addition, when necessary, nutritional supplements should be taken under the control of a physician.
CR  - Al-Toma, A., Volta, U., Auricchio, R., Castillejo, G., Sanders, D. S., Cellier, C., ... Lundin, K. E. A. (2019). European Society for the Study of Coeliac Disease (ESsCD) guideline for coeliac disease and other gluten-related disorders. United European Gastroenterology Journal, 7 (5), 583-613. doi:10.1177/2050640619844125
CR  - Babio, N., Alcazar, M., Castillejo, G., Recasens, M., Martinez-Cerezo, F., Gutierrez-Pensado, V., ... Salas-Salvado, J. (2017). Patients With Celiac Disease Reported Higher Consumption of Added Sugar and Total Fat Than Healthy Individuals. Journal of Pediatric Gastroenterology and Nutrition, 64 (1), 63-69. doi:10.1097/MPG.0000000000001251
CR  - Bai, J. C., Ciacci, C. (2017). World Gastroenterology Organisation Global Guidelines: Celiac Disease February 2017. Journal of Clinical Gastroenterology, 51 (9), 755-768. doi:10.1097/MCG.0000000000000919
CR  - Balamtekin, N., Aksoy, C., Baysoy, G., Uslu, N., Demir, H., Koksal, G., ... Yuce, A. (2015). Is compliance with gluten-free diet sufficient? Diet composition of celiac patients. The Turkish Journal of Pediatrics, 57 (4), 374-379
CR  - Beker Şanlı, D., Aliyazıcıoğlu, Y., Kalaycı, A. G. (2015). Pediatrik çölyak hastalarında homosistein, vitamin B12 ve folik asit düzeyleri. Güncel Pediatri, 13, 1-6. doi: 10.4274/jcp.92400
CR  - Caruso, R., Pallone, F., Stasi, E., Romeo, S., Monteleone, G. (2013). Appropriate nutrient supplementation in celiac disease. Annals of Medicine, 45 (8), 522-531. doi:10.3109/07853890.2013.849383
CR  - Choudhary, G., Gupta, R. K., Beniwal, J. (2017). Bone Mineral Density in Celiac Disease. Indian Journal of Pediatrics, 84 (5), 344-348. doi:10.1007/s12098-016-2273-1
CR  - Choung, R. S., Unalp-Arida, A., Ruhl, C. E., Brantner, T. L., Everhart, J. E., Murray, J. A. (2016). Less Hidden Celiac Disease But Increased Gluten Avoidance Without a Diagnosis in the United States: Findings From the National Health and Nutrition Examination Surveys From 2009 to 2014. Mayo Clinic Proceedings, S0025-6196(16)30634-6. doi:10.1016/j.mayocp.2016.10.012
CR  - Comba, A., Demirbaş, F., Eren, E., Çaltepe, G., Kayadi̇bi̇, H., Kalaycı, A. G. (2018). Çölyak hastalarında serum homosistein düzeylerinin değerlendirilmesi. Pamukkale Tıp Dergisi, 11 (3), 215-222. doi:10.31362/patd.402656
Demirçeken, F. G. (2011). Gluten enteropatisi (Çölyak hastalığı): klasik bir öykü ve güncel gelişmeler. Güncel Gastroenteroloji, 15, 58-72.
CR  - Di Nardo, G., Villa, M. P., Conti, L., Ranucci, G., Pacchiarotti, C., Principessa, L., ... Parisi, P. (2019). Nutritional Deficiencies in Children with Celiac Disease Resulting from a Gluten-Free Diet: A Systematic Review. Nutrients, 11 (7). doi:10.3390/nu11071588
CR  - EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies). (2014a). Scientific opinion on dietary reference values for zinc. EFSA Journal, 12 (10), 3844, 76 pp. doi:10.2903/j.efsa.2014.3844
CR  - EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies). (2014b). Scientific opinion on dietary reference values for folate. EFSA Journal, 12 (11), 3893, 59 pp. doi:10.2903/j.efsa.2014.3893
CR  - EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies). (2015). Scientific opinion on dietary reference values for iron. EFSA Journal, 13 (10), 4254, 115 pp. doi:10.2903/j.efsa.2015.4254
CR  - Faerber, E. (2011). Selenium supplement information for your gluten-free patients. Erişim tarihi 06.10.2020, http://depts.washington.edu/nutr/wordpress/wp-content/uploads/2015/03/Selenium_2012.pdf
CR  - Fathi, F., Ektefa, F., Tafazzoli, M., Rostami, K., Rostami Nejad, M., Fathi, M., … Zali, M. R. (2013). The concentration of serum zinc in celiac patients compared to healthy subjects in Tehran. Gastroenterology and Hepatology from Bed to Bench, 6 (2), 92-95.
CR  - Fernandez, C. B., Varela-Moreiras, G., Ubeda, N., Alonso-Aperte, E. (2019). Nutritional Status in Spanish Children and Adolescents with Celiac Disease on a Gluten Free Diet Compared to Non-Celiac Disease Controls. Nutrients, 11 (10). 2329. doi: 10.3390/nu11102329.
CR  - Foschia, M., Horstmann, S., Arendt, E. K., Zannini, E. (2016). Nutritional therapy - Facing the gap between coeliac disease and gluten-free food. International Journal of Food Microbiology, 239, 113-124. doi:10.1016/j.ijfoodmicro.2016.06.014
CR  - Freeman, H. J. (2015). Iron deficiency anemia in celiac disease. World Journal of Gastroenterology, 21 (31), 9233-9238. doi:10.3748/wjg.v21.i31.9233
CR  - Garcia-Manzanares, A., Lucendo, A. J. (2011). Nutritional and dietary aspects of celiac disease. Nutrition in Clinical Practice, 26 (2), 163-173. doi:10.1177/0884533611399773
CR  - Green, P. H., Lebwohl, B., Greywoode, R. (2015). Celiac disease. The Journal of Allergy and Clinical Immunology, 135 (5), 1099-1106. doi:10.1016/j.jaci.2015.01.044
CR  - Hancock, R., Koren, G. (2004). Celiac disease during pregnancy. Canadian Family Physician Médecin De Famille Canadien, 50, 1361-1363.
CR  - Kavak, U. S., Yuce, A., Kocak, N., Demir, H., Saltik, I. N., Gurakan, F., Ozen, H. (2003). Bone mineral density in children with untreated and treated celiac disease. Journal of Pediatric Gastroenterology and Nutrition, 37 (4), 434-436. doi:10.1097/00005176-200310000-00007
CR  - Kreutz, J. M., Adriaanse, M. P. M., van der Ploeg, E. M. C., Vreugdenhil, A. C. E. (2020). Narrative Review: Nutrient Deficiencies in Adults and Children with Treated and Untreated Celiac Disease. Nutrients, 12 (2). doi:10.3390/nu12020500
CR  - Leivers, C., Martin, G., Gasparetto, M., Shelley, H., Valente, M. (2014). Coeliac disease. Paediatrics and Child Health, 24 (11), 481-484. doi:10.1016/j.paed.2014.05.004
CR  - Mager, D. R., Qiao, J., Turner, J. (2012). Vitamin D and K status influences bone mineral density and bone accrual in children and adolescents with celiac disease. European Journal of Clinical Nutrition, 66 (4), 488-495. doi:10.1038/ejcn.2011.176
CR  - Marti-Carvajal, A. J., Sola, I., Lathyris, D., Dayer, M. (2017). Homocysteine-lowering interventions for preventing cardiovascular events. The Cochrane Database of Systematic Reviews, 8 (8), CD006612. doi:10.1002/14651858.CD006612.pub5
CR  - Martin, J., Geisel, T., Maresch, C., Krieger, K., Stein, J. (2013). Inadequate nutrient intake in patients with celiac disease: results from a German dietary survey. Digestion, 87 (4), 240-246. doi:10.1159/000348850
CR  - Martin-Masot, R., Nestares, M. T., Diaz-Castro, J., Lopez-Aliaga, I., Alferez, M. J. M., Moreno-Fernandez, J., Maldonado, J. (2019). Multifactorial Etiology of Anemia in Celiac Disease and Effect of Gluten-Free Diet: A 
Comprehensive Review. Nutrients, 11 (11), 2557. doi:10.3390/nu11112557
CR  - Nestares, T., Martin-Masot, R., Labella, A., Aparicio, V. A., Flor-Alemany, M., Lopez-Frias, M., Maldonado, J. (2020). Is a Gluten-Free Diet Enough to Maintain Correct Micronutrients Status in Young Patients with Celiac Disease? Nutrients, 12 (3), 844. doi:10.3390/nu12030844
CR  - Niewinski, M. M. (2008). Advances in celiac disease and gluten-free diet. Journal of The American Dietetic Association, 108 (4), 661-672. doi:10.1016/j.jada.2008.01.011
CR  - Niro, S., D'Agostino, A., Fratianni, A., Cinquanta, L., Panfili, G. (2019). Gluten-Free Alternative Grains: Nutritional Evaluation and Bioactive Compounds. Foods, 8 (6), 208. doi:10.3390/foods8060208
CR  - Özkaya, V., Özkaya, Ş. Ö. (2018). Çölyak hastalığına diyetetik yaklaşım. Selçuk Tıp Dergisi, 34 (4), 186-193. doi: 10.30733/std.2018.00906
CR  - Pagano, A. E. (2007). The Gluten-Free Vegetarian. Practical Gastroenterology, 31 (5), 94-106.
CR  - Penagini, F., Dilillo, D., Meneghin, F., Mameli, C., Fabiano, V., Zuccotti, G. V. (2013). Gluten-free diet in children: an approach to a nutritionally adequate and balanced diet. Nutrients, 5 (11), 4553-4565. doi:10.3390/nu5114553
CR  - Popov, J., Baldawi, M., Mbuagbaw, L., Gould, M., Mileski, H., Brill, H., Pai, N. (2018). Iron Status in Pediatric Celiac Disease: A Retrospective Chart Review. Journal of Pediatric Gastroenterology and Nutrition, 66 (4), 651-653. doi:10.1097/MPG.0000000000001761
CR  - Presutti, R. J., Cangemi, J. R., Cassidy, H. D., Hill, D. A. (2007). Celiac disease. American Family Physician, 76 (12), 1795-1802.
CR  - Reilly, N. R. (2016). The Gluten-Free Diet: Recognizing Fact, Fiction, and Fad. The Journal of Pediatrics, 175, 206-210. doi:10.1016/j.jpeds.2016.04.014
CR  - Rondanelli, M., Faliva, M. A., Gasparri, C., Peroni, G., Naso, M., Picciotto, G., ... Perna, S. (2019). Micronutrients Dietary Supplementation Advices for Celiac Patients on Long-Term Gluten-Free Diet with Good Compliance: A Review. Medicina (Kaunas), 55 (7), 337. doi:10.3390/medicina55070337
CR  - Rubio-Tapia, A., Hill, I. D., Kelly, C. P., Calderwood, A. H., Murray, J. A. (2013). ACG clinical guidelines: diagnosis and management of celiac disease. The American Journal of Gastroenterology, 108 (5), 656-676. doi:10.1038/ajg.2013.79
CR  - Rujner, J., Socha, J., Syczewska, M., Wojtasik, A., Kunachowicz, H., Stolarczyk, A. (2004). Magnesium status in children and adolescents with coeliac disease without malabsorption symptoms. Clinical Nutrition, 23 (5), 1074-1079. doi:10.1016/j.clnu.2003.10.018
CR  - Saturni, L., Ferretti, G., Bacchetti, T. (2010). The gluten-free diet: safety and nutritional quality. Nutrients, 2 (1), 16-34. doi:10.3390/nu2010016
CR  - See, J., Murray, J. A. (2006). Gluten-free diet: the medical and nutrition management of celiac disease. Nutrition in Clinical Practice, 21 (1), 1-15. doi:10.1177/011542650602100101
CR  - Serin, Y., Akbulut, G. (2017). Çölyak hastalığı ve glutensiz diyet tedavisine güncel yaklaşım. Türkiye Klinikleri Journal of Health Sciences, 2 (3), 192-200. doi: 10.5336/healthsci.2016-53640
CR  - Simpson, S., Thompson, T. (2012). Nutrition assessment in celiac disease. Gastrointestinal Endoscopy Clinics of North America, 22 (4), 797-809. doi:10.1016/j.giec.2012.07.010
CR  - Singh, P., Arora, A., Strand, T. A., Leffler, D. A., Catassi, C., Green, P. H., … Makharia, G. K. (2018). Global Prevalence of Celiac Disease: Systematic Review and Meta-analysis. Clinical Gastroenterology and Hepatology, 16 (6), 823-836.e2. doi:10.1016/j.cgh.2017.06.037
CR  - Theethira, T. G., Dennis, M. (2015). Celiac disease and the gluten-free diet: consequences and recommendations for improvement. Digestive Diseases, 33 (2), 175-182. doi:10.1159/000369504
CR  - Thompson, T. (1999). Thiamin, riboflavin, and niacin contents of the gluten-free diet: is there cause for concern? Journal of the American Dietetic Association, 99 (7), 858-862. doi:10.1016/S0002-8223(99)00205-9
CR  - Thompson, T., Dennis, M., Higgins, L. A., Lee, A. R., Sharrett, M. K. (2005). Gluten-free diet survey: are Americans with coeliac disease consuming recommended amounts of fibre, iron, calcium and grain foods? Journal of Human Nutrition and Dietetics, 18 (3), 163-169. doi:10.1111/j.1365-277X.2005.00607.x
CR  - Türkiye Cumhuriyeti Sağlık Bakanlığı Halk Sağlığı Genel Müdürlüğü. (2017). Çölyak ve Görülme Sıklığı. Erişim tarihi 06.10.2020, https://hsgm.saglik.gov.tr/tr/metabolizma-ve-colyak/%C3%A7%C3%B6lyak-ve-g%C3%B6r%C3%BClme-s%C4%B1kl%C4%B1%C4%9F%C4%B1.html
CR  - Türkiye Cumhuriyeti Sağlık Bakanlığı Halk Sağlığı Genel Müdürlüğü Sağlıklı Beslenme ve Hareketli Hayat Daire Başkanlığı. (2019). Çölyak Hastalığında Aile Hekimleri İçin Tanı, Tedavi ve İzlem Rehberi, Sağlık Bakanlığı Yayın No: 1111, Ankara.
CR  - Ünal, F., Umman, C., Cebe Tok, A., Semizel, E., Ecevit, Ç. Ö., Özdemir, S., ... Kasırga, E. (2012). Glutensiz diyet alan çölyak hastası çocuklarda serum selenyum düzeyleri. Güncel Pediatri, 10 (2), 55-58.
CR  - Valente, F. X., Campos, T., N., Moraes, L. F. S., Hermsdorff, H. H. M., Cardoso, L., M., Pinheiro-Sant'Ana, H. M., ... Peluzio, M. C. G. (2015). B vitamins related to homocysteine metabolism in adults celiac disease patients: a cross-sectional study. Nutrition Journal, 14, 110. doi:10.1186/s12937-015-0099-8
CR  - Vici, G., Belli, L., Biondi, M., Polzonetti, V. (2016). Gluten free diet and nutrient deficiencies: A review. Clinical Nutrition, 35 (6), 1236-1241. doi:10.1016/j.clnu.2016.05.002
CR  - Zanchetta, M. B., Longobardi, V., Bai, J. C. (2016). Bone and Celiac Disease. Current Osteoporosis Reports, 14 (2), 43-48. doi:10.1007/s11914-016-0304-5
CR  - Zylberberg, H. M., Lebwohl, B., RoyChoudhury, A., Walker, M. D., Green, P. H. R. (2018). Predictors of improvement in bone mineral density after celiac disease diagnosis. Endocrine, 59 (2), 311-318. doi:10.1007/s12020-017-1488-x
UR  - https://doi.org/10.46413/boneyusbad.807225
L1  - https://dergipark.org.tr/en/download/article-file/1333742
ER  -