
   @article{article_813955, title={Thiol/disulphide balance and ischemia modified albumin levels in relapsed brucellosis patients}, journal={The European Research Journal}, volume={8}, pages={59–64}, year={2022}, DOI={10.18621/eurj.813955}, author={Aslan, Mehtap Hülya and Karasahin, Omer and İba Yılmaz, Sibel and Kurt, Ali and Baran, Pervin and Koca Biçer, Cemile}, keywords={Relapse brucellosis, thiol/disulphide, ischemia modified albumin}, abstract={&amp;lt;p&amp;gt; &amp;lt;b&amp;gt;Objectives: &amp;lt;/b&amp;gt;In the study, it was aimed to determine the Thiol/Disulphide profile in patients with relapsed brucellosis and the relationship between Ischemia Modified Albumin (IMA) Levels and Thiol/Disulphide profile. &amp;lt;/p&amp;gt; &amp;lt;p&amp;gt; &amp;lt;b&amp;gt;
Methods: &amp;lt;/b&amp;gt; Native thiol, Total thiol, Disulphide, Disulphide/Native thiol, Disulphide/Total thiol, IMA levels were measured in forty patients with relapsed brucellosis and healthy control group by using the newly developed method in this cross-sectional study. &amp;lt;/p&amp;gt; &amp;lt;p&amp;gt; &amp;lt;b&amp;gt;
Results: &amp;lt;/b&amp;gt; There was no statistically significant difference in patients with relapse brucellosis despite the fact that it was lower than total thiol control group ( &amp;lt;i&amp;gt;p &amp;lt;/i&amp;gt; &amp;gt; 0.05). Disulphide was detected high in patients with brucellosis but no statistically significant difference was found (p &amp;gt; 0.05). Native thiol and total thiol ratios of disulphide were found to be statistically higher in patients with relapsed brucellosis ( &amp;lt;i&amp;gt;p &amp;lt;/i&amp;gt; &amp;lt; 0.05). In addition, the ratio of native thiol and native thiol to total thiol was statistically lower than the control group ( &amp;lt;i&amp;gt;p &amp;lt;/i&amp;gt; &amp;lt; 0.05). The levels of IMA were statistically significant in patients with relapsed brucellosis compared to the control group ( &amp;lt;i&amp;gt;p &amp;lt;/i&amp;gt; &amp;lt;0.05). There was a statistically significant positive correlation between IMA values and Disulphide and Disulphide/Native thiol, Disulphide/Total thiol, Native thiol/Total thiol ratios (r=0.514, r=0.527, r=0.527, r=0.527; respectively). &amp;lt;/p&amp;gt; &amp;lt;p&amp;gt; &amp;lt;b&amp;gt;
Conclusions: &amp;lt;/b&amp;gt; It is known that the response of brucellosis treatment can be followed up with oxidative stress markers and it can also be used as a relapse indicator in our study. &amp;lt;/p&amp;gt;}, number={1}, publisher={Prusa Medical Publishing}