TY  - JOUR
T1  - Ege Üniversitesi hastanesi veri tabanında çoklu primer kanserlerin analizi
TT  - The analysis of multiple primary cancers in Ege University hospital database
AU  - Caner, Ayşe
AU  - Haydaroğlu, Ayfer
AU  - Sert, Fatma
PY  - 2020
DA  - October
DO  - 10.19161/etd.814839
JF  - Ege Tıp Dergisi
JO  - EJM
PB  - Ege University
WT  - DergiPark
SN  - 1016-9113
SP  - 1
EP  - 5
LA  - tr
AB  - Amaç: Ege Üniversitesi Hastanesi (EÜH) kanser veri tabanında birden çok sayıda kanserleri olanÇoklu Primer Kanser (ÇPK)’li olguların sayıca artışı dikkat çekici bulunmuş, bu artışın istatistik olarakanalizi planlanmıştır.Gereç ve Yöntem: EÜH’de EÜKAM tarafından CANREG-4 özel bilgisayar programına kayıt edilenkanser verileri WHO ve Surveillance, Epidemiology, and End Results (SEER) sistemleri temelindegruplanarak analizler yapılmıştır. İstatistik analizlerde Ki-kare, General Linear Model, Kaplan Meiersağkalım analizleri uygulanmıştır. Kaplan Meier Sağkalım analizinde Log Rank (Mantel-Cox), Breslow(Generalized Wilcoxon) ve Tarone-Ware istatistikleri kullanılmış, istatistik analizlerde p <0,05istatistiksel olarak anlamlı kabul edilmiştir.Bulgular: EÜH veri tabanında 1992-2018 yılları arasında kaydedilmiş 124.321 kanser olgusunun6.311’inde birden çok kanser (%5,1) saptanmıştır. ÇPK görülüşü erkeklerde daha belirgindir(p<0,0001). ÇPK’de yıllara göre bir artış saptanmıştır (p<0,0001). Her iki cinste en sık görülenGastrointestinal sistem (GİS) kanserlerinde ÇPK genellikle yine GİS ile ilgili olmakta, bunu ürogenitalsistem (ÜGS) kanserleri izlemektedir. Akciğer kanseri ile beraber görülen ÇPK’lerin başında diğersolunum sistemi kanserleri gelmekte, bunu mesane kanserleri izlemektedir. Meme kanserini izleyenÇPK’ler endometrium ve over kanseridir. ÇPK’lerde sağkalım tek primer kanserlilere göre daha kötüve çoklu ÇPK sayısı arttıkça sağkalımlar daha kötü olmaktadır (p<0,001). Olguların %18,2’si senkron,%81,8’i metakron olup sağkalım açısından istatistiksel olarak aradaki fark anlamlı değildir (p=0,506).Sonuç: EÜH Hastanesi veri tabanında %5,1 ÇPK saptanmış olup yıllara göre bir artış eğilimi vardır.Senkron veya metakron gelişen ÇPK’lar da sağkalım farkı bulunmamıştır. Çoklu primer kanserlerdesağkalım tekli kanserlere göre daha kötü olup ÇPK sayısı arttıkça GSK’lar daha kötü olmaktadır.
KW  - Çoklu primer kanserler
KW  - epidemiyoloji
KW  - genel sağkalım
N2  - Aim: To evaluate the remarkable increase in the incidence of multiple primary cancers (MPCs) in thecancer database of Ege University Hospital (EUH).Materials and Methods: The data recorded in CANREG from EUKAM, which is special computerprogram, were grouped on the basis of WHO and SEER systems and analyzes were performed. Instatistical analysis, chi-square, General Linear Model, and Kaplan-Meier survival curves were used.Log-Rank (Mantel-Cox), Breslow (Generalized Wilcoxon), and Tarone-Ware statistics were applied forsurvival analysis. p<0.05 was accepted statistically significant.Results: The total number of recorded cancer patients between 1992-2018 years was 124,321. Theproportion of patients with MPCs during the searched period was 5.1% (n=6,311). MPCs weredetected more common in men than in women (p<0.001).There was an increase in the incidence of MPCs over years. MPCs were most commonly detected inthe gastrointestinal system (GIS) in both sexes. GIS cancers were seen as a secondary for GIS itselfand GIS cancers were followed by urogenital system (UGS) cancers. MPCs seen with lung cancerwere other respiratory organ cancers, as well. Bladder cancers were other commonly detected MPCswith lung cancer. Endometrium and ovary cancers were cancers which were seen as MPCs afterbreast cancer. Survival in MPCs was worse than in single primary cancers. Additionally, Overallsurvival rates were getting worse accordingly to the increase in MPCs number (p<0.001). 18.2% of thecases are synchronous, 81.7% of them are metachronous and there is no statistically significantdifference in survival (p=0.506).Conclusion: In EUH cancer database, 5.1 % MPCs were detected and there was an increasing trendover the years. There is no statistically significant difference in survival of synchronous andmetachronous MPCs. Survival in MPCs was worse than in single primary cancers and Overall survivalrates were getting worse accordingly to the increase in MPCs number.
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UR  - https://doi.org/10.19161/etd.814839
L1  - https://dergipark.org.tr/en/download/article-file/1362014
ER  -