TY  - JOUR
T1  - Amelioration of External Surgical Wound by Topical Application of the Aqueous Formulation of Neem Leaves (Azadirachta indica) in Caprine Model
AU  - Alam, Md. Mahmudul
AU  - Sultana, Ajmary
AU  - Rahman, Marzia
PY  - 2020
DA  - December
DO  - 10.38093/cupmap.828751
JF  - Current Perspectives on Medicinal and Aromatic Plants
JO  - CUPMAP
PB  - Nazım ŞEKEROĞLU
WT  - DergiPark
SN  - 2619-9645
SP  - 87
EP  - 96
VL  - 3
IS  - 2
LA  - en
AB  - The study was conducted to evaluate the healing potentials of Neem leaf on surgical wounds. A total of sixteen surgical wounds were studied under two groups; Neem (group A) and Normal saline (group B, control). Wound morphology,  histopathology, and bacteriological examinations were carried out to assess wound healing potentials of this plant leaves. We have found a remarkably lower swollen area (3.91±0.10mm), suture line levation (2.64±0.19mm) and length of the wound (15.78±0.19mm) in the treatment group than the control (0.36±0.12mm, 3.59±0.12mm, and 17.11±0.08mm respectively). The mean healing period Neem treated wound was significantly (P<0.05) lower (12.33±0.42 days) than that of control (18.67±0.33 days). Histopathological study revealed the presence of substantial inflammation with fibroblastic proliferation in samples collected at day 3 in the control group whereas these features were distinctly reduced in the treatment group. There was a distinct thickening of the keratinized layer of the epidermis in Neem treated wound on day 21. In bacteriological study, huge bacterial colonies were found on day 3 in the control group whereas this was markedly reduced in number in the wound of Group-A. Thus, the present study supports the scientific rationale for the use of Neem leaf in the management of wounds.
KW  - Neem leaf
KW  - Surgical wound
KW  - Histopathology
KW  - Bacteriology
KW  - Amelioration
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UR  - https://doi.org/10.38093/cupmap.828751
L1  - https://dergipark.org.tr/en/download/article-file/1406750
ER  -