TY - JOUR T1 - Yetişkin Nörogenez ve Nörodejeneratif Hastalıklarda Büyüme Faktörlerinin Rolü TT - The Role of Growth Factors in Adult Neurogenesis and Neurodegenerative Diseases AU - Sozer Tokdemir, Selcuk AU - Toprak, Fatih AU - Toprak, Selin PY - 2021 DA - May DO - 10.26650/experimed.2021.831169 JF - Experimed PB - Istanbul University WT - DergiPark SN - 2667-5846 SP - 57 EP - 66 VL - 11 IS - 1 LA - tr AB - Nörogenez, nöral kök hücrelerin (NKH) bölünme, göç etme ve fark-lılaşma süreçlerinin bütününü oluşturmaktadır. Lateral ventrikülün subventriküler bölgesi (SVZ) ve hipokampus dentat girus (DG)’daki subgranüler bölge (SGZ) olmak üzere iki farklı nişte gerçekleşmek-tedir. Nörotrofik faktörler, NKH ve nöral progenitor hücrelerin mig-rasyon, proliferasyon ve farklılaşmasında rol oynar. Ayrıca, NKH’le-rin hasarlı dokuda, nöral hücrelerin yeniden yapılanması, nöral plastisite ve anjiogenezi düzenleyici etkileri olduğu gösterilmiştir. Yetişkin nörogenezinde ise nörotrofik faktör kombinasyonlarının serebrovasküler, nörodejeneratif, onkolojik hastalıklar ve travma sonrası oluşan inflamatuvar hasar tedavisinde önemli rolü olduğu bilinmektedir. Bu derlemede, nörotrofik faktörlerin NKH’ler üzerin-deki modüle edici etkisi ve potansiyel terapötik uygulamalarında preklinik ve klinik çalışmaları içeren güncel literatürler biraraya ge-tirilmiştir. Bu alanda çalışma yapan araştırmacı ve hekimlere fayda sağlayacak güncel bilgiler içermektedir. KW - Nörogenez KW - nörotrofik faktör KW - nöral kök hücre N2 - Neurogenesis is the combined processes of division, migration and differentiation of neural stem cells (NSCs). The two different loca-tions: the subventricular zone (SVZ) of the lateral ventricle and the subgranular zone (SGZ) in the hippocampus dentate gyrus (DG), provide a niche environment for neurogenesis. Neurotrophic fac-tors have roles on migration, proliferation and differentiation of NSC and neural progenitor cells. 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[CrossRef] google scholar UR - https://doi.org/10.26650/experimed.2021.831169 L1 - https://dergipark.org.tr/en/download/article-file/1414698 ER -