TY  - JOUR
T1  - Screening Design of Experiment Applied to Dispersive Liquid-Liquid Microextraction of UV Filters from Water
AU  - Lukıć, Jelena
AU  - đurkıć, Tatjana
AU  - Radulovıć, Jelena
AU  - Bakıć, Tamara
AU  - Onjıa, Antonije
PY  - 2020
DA  - December
JF  - The Eurasia Proceedings of Science Technology Engineering and Mathematics
JO  - EPSTEM
PB  - ISRES Publishing
WT  - DergiPark
SN  - 2602-3199
SP  - 1
EP  - 4
VL  - 11
LA  - en
AB  - A Plackett-Burman factorial design (PBD) has been used for the optimization of dispersive liquid-liquid microextraction (DLLME) of UV filters from water. The experimental procedure included a DLLME sample preparation prior to high-performance liquid chromatography triple quadrupole mass spectrometry (HPLC-MS/MS) measurements. The variables of the DLLME process for simultaneous preconcentration of UV filters (avobenzone and octocrylene) have been studied using PBD with twelve experimental runs. Several experimental variables including the extractant type, pH value, the disperser type, extractant volume, disperser volume, vortexing/sonication, centrifugation speed, reconstitution solvent, salt content, temperature, and centrifugation time were considered in the optimization process. PBD results revealed the most important variables that affected the extraction efficiency (EF). The first three most influential variables, as showed using a Pareto graph, were in the following order: the extractant volume > the disperser type > the extraction temperature. Based on the main effects plot, it was revealed that some variables (pH value, the disperser type, extractant volume, temperature, centrifugation speed, salt content) increased over the experimental domain, while the others (the extractant type, disperser volume, vortexing/sonication, centrifugation time, reconstitution solvent) decreased
KW  - UV filters
KW  - Plackett- Burman
KW  - DLLME
KW  - HPLC-MS/MS
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CR  - Chisvert, A., & Salvador, A. (2018). Ultraviolet Filters in Cosmetics : Regulatory Aspects and Analytical Methods. In Analysis of Cosmetic Products (Second Edi). Elsevier B.V.
CR  - Chisvert, A., Benedé, J. L., & Salvador, A. (2018). Current trends on the determination of organic UV filters in environmental water samples based on microextraction techniques – A review. Analytica Chimica Acta, 1034, 22–38.
CR  - Onjia, A. (2016). Chemometric approach to the experiment optimization and data evaluation in analytical chemistry. Faculty of Technology and Metallurgy, University of Belgrade Publication, Serbia, p. 143.
CR  - Ramos, S., Homem, V., & Santos, L. (2019). Simultaneous determination of synthetic musks and UV-filters in water matrices by dispersive liquid-liquid microextraction followed by gas chromatography tandem mass-spectrometry. Journal of Chromatography A, 1590(2018), 47–57.
UR  - https://dergipark.org.tr/en/pub/epstem/issue//836125
L1  - https://dergipark.org.tr/en/download/article-file/1431930
ER  -