@article{article_838615, title={Prognostic value of metastatic lymph node ratio in locally advanced breast cancer}, journal={Turkish Journal of Clinics and Laboratory}, volume={13}, pages={1–8}, year={2022}, DOI={10.18663/tjcl.838615}, author={Benli, Sami and Aksoy, Suleyman and Saydam, Mehmet Serdar and Durak, Merih}, keywords={breast cancer, lymph node ratio, survival}, abstract={Aim: In this study we evaluated the prognostic value of the lymph node ratio. (LNR: defined as the number of involved nodes divided by the number of the nodes examined). Patients and Methods: In this retrospective study, patients underwent axillary dissection due to breast cancer were examined. We evaluated 348 women underwent axillary dissection for nonmetastatic breast cancer in 9 Eylül University Hospital between 2006 and 2016. LNR were divided into three groups as low, intermediate and high risk (low, ≤0.20; intermediate, 0.21-0.65; high, > 0.65). Overall survival of the patients was estimated by the Kaplan Meier method for LNR. Overall relative mortality risks associated with LNR and pN were calculated by Cox regression. Results: The mean survival was 95.1 months LNR high-risk group, while it was 100 months in N3 group. Even though it was not statistically significant, a lower survival rate of less than 5 months was observed in the LNR high group (P <0.74). High LNR associated with poor dissease specific survival rates with the mean 76.73 months of follow up. In the multivariate analysis, high LNR was an independent poor prognostic factor in breast cancer (LNR>0.65 HR 3.08; p=0.002). Conclusion: LNR is highly significant in breast cancer and it provides more valuable information rather than TNM in terms of prognosis. Therefore, we think that, LNR can be used as a beneficial tool in breast cancer staging.}, number={1}, publisher={DNT Ortadoğu Yayıncılık A.Ş.}