@article{article_849031, title={Florfenicol Therapy During Naturally Occuring Corynebacterium pseudotuberculosis Infection in Sheep and Goats in Aydin, Turkey}, journal={Animal Health Production and Hygiene}, volume={3}, pages={278–283}, year={2014}, author={Ural, Kerem and Kirkan, Şükrü and Ural, Deniz Alıç and Erbas, Göksel and Gültekin, Mehmet and Parın, Uğur and Balıkçı, Canberk}, keywords={Corynebacterium pseudotuberculosis,Identification,Sheep,Goat,Florfenicol.}, abstract={Background/Aim: Caseous Lymphadenitis is a bacterial disease of chronic suppurative lymphadenitis of both goat and sheep resulting within major economic consequences. Given the distribution of the disease throughout the vast majority of the world, it has also been frequently decribed and found in Turkey. Condemnation of skins and carcasses due to abscess formation, severe losses in reproductive efficiency and in wool, meat and milk production all results in economic losses. The eradication is of difficult due to rapid spread of the disease once introduced into a flock. Treatment options with antibiotic application may not be efficicaous, indeed C. pseudotuberculosis is sensitive in vitro to the vast majority of antibiotics that have been tested. The intracellular location of the bacteria and the occurence of biofilm in naturally forming infections diminishes drug efficacy, making most of the antimicrobials inefficient. Anyhow it should not be unwise to suggest that there is clearly a need for an effective antimicrobial therapy. The present randomized field study was carried out to measure the effects of florfenicol treatment regime on Corynebacterium pseudotuberculosis infection in a mixed goat and sheep herd located in Aydin, Turkey. Materials and Methods: All cases included were diagnosed cases of C. pseudotuberculosis abscesses located in several lymph nodes. The most prominent site of the abscesses were in the anterior half of the body both in sheep and goats. Two groups of animals were randomly assigned: Group F n=8 goat, 6 sheep, treatment group received florfenicol five daily subcutaneous doses of 40 mg/kg ; Group C n=6 goat, 6 sheep, control group served as positive untreated control. Results and Conclusion: The efficacy of florfenicol was assessed clinically and based on a lesion score derived from the examination of the lesional lymph nodes. Clinical evaluation and lesion scoring were performed by a blinded researcher. Throughout the study florfenicol treatment significantly decrased P˂0.05 the clinical score while no significant changes were detected in the control group.}, number={1}, publisher={Aydin Adnan Menderes University}