TY  - JOUR
T1  - Effect of Sildenafil Citrate on Uterine Artery Doppler Indices in Non-pregnant Rabbits
AU  - Peker, Cevdet
AU  - Küçük, Niyazi
AU  - Uçar, Eyüp Hakan
AU  - Erdoğan, Güneş
PY  - 2020
DA  - June
JF  - Animal Health Production and Hygiene
JO  - Animal Health, Prod and Hyg
PB  - Aydin Adnan Menderes University
WT  - DergiPark
SN  - 2146-7269
SP  - 685
EP  - 688
VL  - 9
IS  - 1
LA  - en
AB  - The effect of different doses of sildenafil citrate (SC) administrations on arteria (a.) uterine blood flow was investigated in healthyfemale rabbits. Twelve healthy non-pregnant New Zealand rabbits were used in the present study. In the first experimental group(n=6), 5 mg SC thawed in 0.9% NaCl solution was administered orally. Arteria uterina was examined with Pulsed Doppler ultrasonographyat pre and post (60 minutes) SC administration. Heart rate (HR), pulsatility index (PI) and resistance index (RI) valueswere recorded from the a. uterina visualized with cervical channels. Similarly, the study was repeated in second experimentalgroup (n=6) by using 10 mg SC for per animal. In the first experiment, the mean HR, PI and RI values were recorded as (223 ± 7.80& 239 ± 15.00), (1.60 ± 0.08 & 1.63 ± 0.16) and (0.73 ± 0.02 & 0.73 ± 0.03) before and after SC administration, respectively. In thesecond experiment, the mean HR, PI and RI values were observed as (210 ± 15.00 & 223 ± 14.00), (1.46 ± 0.23 & 1.79 ± 0.08) and(0.68 ± 0.05 & 0.77 ± 0.01) before and after SC administration, respectively.No significant difference was between pre and post-administration Doppler parameters in both experiments (P>0.05). Consequently,no enhancing effect on the uterine perfusion was observed in oral 5 and 10 mg SC administrations per rabbit.
KW  - doppler
KW  - uterine artery
KW  - sildenafil citrate
KW  - rabbit
CR  - Referans1 Ballard, S.A., Gingell, C.J., Tang, K., Turner, L.A., Prive, M.E., & Naylor, A.M. (1998). Effect of sildenafil on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isozymes. Journal of Urology, 159(6), 2164- 2171. https://doi.org/10.1016/S0022-5347(01)63299-3
CR  - Referans2 Batissaco, L., Celeghini, E. C., Pinaffi, F. L., Oliveira, B. M., Andrade,A., Recalde, E. C., & Fernandes, C. (2013). Correlations betweentesticular hemodynamic and sperm characteristics in rams.Brazilian Journal of Veterinary Research and Animal Science, 50(5),384-395. https://doi.org/10.11606/issn.2318-3659.v50i5p384-395
UR  - https://dergipark.org.tr/en/pub/aduveterinary/issue//854505
L1  - https://dergipark.org.tr/en/download/article-file/1490381
ER  -