@article{article_859897, title={Combinations of Interleukin-10 gene promoter polymorphisms with -1082A, -819T, -592A minor allele are associated with sinonasal polyposis}, journal={Hittite Journal of Science and Engineering}, volume={5}, pages={285–292}, year={2018}, DOI={10.17350/HJSE19030000105}, author={Ozdas, Sibel}, keywords={Sinonasal polyposis,IL-10 gene,Single nucleotide polymorphisms,Interaction,Multifactor dimensionality reduction.}, abstract={S inonasal polyposis SP is an inflammatory disease involving multiple etiologies and pathogenesis. The disarray of Interleukin IL -10 is associated with a raised immunopathological response during the progression of many autoimmune diseases as well as the response to infection. We studied the possible role of the single nucleotide polymorphisms SNPs in IL-10 gene and their genotypic combinations in the SP pathogenesis. The IL-10’s promoter was genotyped in 200 participants 100 patients and 100 controls . The sites that were encompassed -1082, -819, and -592 SNP regions of extracted DNAs were analyzed by sequencing for polymorphisms. The IL-10 gene promoter polymorphisms with -1082A, -819T, -592A minor alleles, their heterozygotes and homozygotes mutant genotypes hadsigniŞcantly higher risks for SP P}, number={4}, publisher={Hitit University}