TY - JOUR T1 - Can persistent hiccups be a progression marker in COVID-19? AU - Alay, Handan AU - Doğan, Nazım AU - Özkurt, Zülal AU - Bilge, Nuray AU - Kesmez Can, Fatma AU - Araz, Ömer PY - 2021 DA - March DO - 10.32322/jhsm.867371 JF - Journal of Health Sciences and Medicine JO - J Health Sci Med /JHSM /jhsm PB - MediHealth Academy Yayıncılık WT - DergiPark SN - 2636-8579 SP - 240 EP - 242 VL - 4 IS - 2 LA - en AB - Hiccup is a reflex action that may rarely be intractable. A 55-year-old man diagnosed with COVID-19 was hospitalized to our clinic with body temperature elevation, weakness, and headache persisting for the previous three days. Persistent hiccups were present during follow-up, and progression was observed at pulmonary tomography with an increase in the numbers and dimensions of focal ground glass areas. Lymphocyte count was 920/µL, platelet count 138X103/µL, sedimentation rate 6 mm/h, ferritin 1256 ng/mL, C-reactive protein 16.8 mg/L, aspartate aminotransferase 43 U/L, alanine aminotransferase 67 U/L, and lactate dehydrogenase 326 U/L. Other potential causes of persistent hiccups were excluded. COVID-19 immune plasma and remdesivir therapy were initiated. The hiccups resolved two days after treatment, and the patient was discharged on the 11th day of follow-up. Persistent hiccups should be remembered among the symptoms that may appear during the clinical progression of COVID-19. KW - Persistent hiccups KW - progression KW - COVID-19 CR - World Health Organization. Director-General's remarks at the media briefing on 2019-nCoV on 11 February 2020. http://www.who.int/dg/speeches/detail/who-director-general-s-remarks-at-the-media-briefing-on-2019-ncov-on-11-february-2020 (Accessed on October 12, 2020). CR - Lu R, Zhao X, Li J, et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet 2020; 395: 565–74. CR - Hamming I, Timens W, Bulthuis ML, Lely AT, Navis G, van Goor H. Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis. J Pathol 2004; 203: 631–7. CR - Guan W-J, Ni Z-Y, Hu Y, et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med 2020. doi:10.1056/NEJMoa2002032. CR - Hopkins C, Kumar N (2020) Loss of sense of smell as a marker of COVID-19 infection. ENTUK (cited 2020 November 12); Available from https://www.entuk.org/sites/default/files/files/Loss%20of%20sense%20of%20smell%20as%20marker%20of%20COVID.pdf CR - Mao L. Neurological manifestations of hospitalized patients with COVID-19 in Wuhan. China: retrospective case series study. 2020. CR - Alay H, Gözgeç E. Cerebral ınfarction in an elderly patient with coronavirus disease. Rev Soc Bras Med 2020; 53: e20200307. CR - Smith HS, Busracamwongs A. Management of hiccups in the palliative care population. Am J Hosp Palliat Care. 2003; 20: 149. CR - Souadjian JV, Cain JC. Intractable hiccup. Etiologic factors in 220 cases. Postgrad Med 1968; 43: 72. CR - Prince G, Sergel M. Persistent hiccups as an atypical presenting complaint of COVID-19. Am J Emerg Med 2020; 38: 1546.e5-1546.e6. UR - https://doi.org/10.32322/jhsm.867371 L1 - https://dergipark.org.tr/en/download/article-file/1530080 ER -